Department of Bio-engineering Sciences

Postal address
Pleinlaan 2
1050
Brussels
Belgium
Contact
Phone: +32-2-3590248

Structural Biology Brussels

Postal address
Pleinlaan 2
1050
Brussels
Belgium

Expertise

Last years, the Steyaert lab pioneered the use of nanobodies for chaperone-assisted X-ray crystallography (www.steyaertlab.eu), aiming at the highest hanging fruits of structural biology including membrane proteins, amyloidogenic proteins, and now also (transient) multiprotein complexes. The elucidation of the first GPCR structures in the agonist-bound active state demonstrate the power of Nanobodies to stabilize G protein coupled receptor conformational states including transmembrane signalling complexes. Recent work focusses on exploiting the conformational complexity of therapeutic targets for Nanobody-enabled drug discovery.

Research output

  1. Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax

    Research output: Contribution to journalArticleResearchpeer-review

  2. A lipid site shapes the agonist response of a pentameric ligand-gated ion channel

    Research output: Contribution to journalArticleResearchpeer-review

  3. Structures of influenza A virus RNA polymerase offer insight into viral genome replication

    Research output: Contribution to journalArticleResearchpeer-review

View all (221) »

Activities

  1. 42d FEBS Congress

    Activity: Talk or presentationTalk or presentation at a conference

  2. Lezing voor Internationalisation@Home

    Activity: Talk or presentationTalk at an external academic organisation

  3. EU project 731005 - INSTRUCT-ULTRA

    Activity: Participating in or organising an eventParticipation in workshop, seminar

View all (56) »

ID: 192356