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Varenicline increases striatal dopamine D(2/3) receptor binding in rats. / Crunelle, Cleo; Miller, ML; de Bruin, K; Van Den Brink, W.; Booij, J.

In: Addiction Biology, Vol. 14, No. 4, 09.2009, p. 500-502.

Research output: Contribution to journalArticle

Harvard

Crunelle, C, Miller, ML, de Bruin, K, Van Den Brink, W & Booij, J 2009, 'Varenicline increases striatal dopamine D(2/3) receptor binding in rats.', Addiction Biology, vol. 14, no. 4, pp. 500-502. https://doi.org/doi: 10.1111/j.1369-1600.2009.00168.x

APA

Crunelle, C., Miller, ML., de Bruin, K., Van Den Brink, W., & Booij, J. (2009). Varenicline increases striatal dopamine D(2/3) receptor binding in rats. Addiction Biology, 14(4), 500-502. https://doi.org/doi: 10.1111/j.1369-1600.2009.00168.x

Vancouver

Crunelle C, Miller ML, de Bruin K, Van Den Brink W, Booij J. Varenicline increases striatal dopamine D(2/3) receptor binding in rats. Addiction Biology. 2009 Sep;14(4):500-502. https://doi.org/doi: 10.1111/j.1369-1600.2009.00168.x

Author

Crunelle, Cleo ; Miller, ML ; de Bruin, K ; Van Den Brink, W. ; Booij, J. / Varenicline increases striatal dopamine D(2/3) receptor binding in rats. In: Addiction Biology. 2009 ; Vol. 14, No. 4. pp. 500-502.

BibTeX

@article{0df70ca4c60d4719892d9974a638eb69,
title = "Varenicline increases striatal dopamine D(2/3) receptor binding in rats.",
abstract = "Increasing dopamine D(2/3) receptor availability is postulated to be a treatment for drug addiction. Varenicline, an alpha4beta2-nicotinic partial agonist, is effective for nicotine dependence. We hypothesize that varenicline increases dopamine D(2/3) receptor availability. Twenty male drug-na{\"i}ve rats were randomized to varenicline (2 mg/kg) or placebo for 14 days, and then injected with the dopamine D(2/3) radiotracer 123I-IBZM. We found significantly higher striatum-to-cerebellum binding ratios in both dorsal and ventral striatum for the varenicline group compared with placebo. Varenicline increases dopamine D(2/3) receptor availability in drug-na{\"i}ve rats. Therefore, varenicline may be an effective treatment for addictions other than smoking.",
author = "Cleo Crunelle and ML Miller and {de Bruin}, K and {Van Den Brink}, W. and J Booij",
year = "2009",
month = "9",
doi = "doi: 10.1111/j.1369-1600.2009.00168.x",
language = "English",
volume = "14",
pages = "500--502",
journal = "Addiction Biology",
issn = "1355-6215",
publisher = "Wiley",
number = "4",

}

RIS

TY - JOUR

T1 - Varenicline increases striatal dopamine D(2/3) receptor binding in rats.

AU - Crunelle, Cleo

AU - Miller, ML

AU - de Bruin, K

AU - Van Den Brink, W.

AU - Booij, J

PY - 2009/9

Y1 - 2009/9

N2 - Increasing dopamine D(2/3) receptor availability is postulated to be a treatment for drug addiction. Varenicline, an alpha4beta2-nicotinic partial agonist, is effective for nicotine dependence. We hypothesize that varenicline increases dopamine D(2/3) receptor availability. Twenty male drug-naïve rats were randomized to varenicline (2 mg/kg) or placebo for 14 days, and then injected with the dopamine D(2/3) radiotracer 123I-IBZM. We found significantly higher striatum-to-cerebellum binding ratios in both dorsal and ventral striatum for the varenicline group compared with placebo. Varenicline increases dopamine D(2/3) receptor availability in drug-naïve rats. Therefore, varenicline may be an effective treatment for addictions other than smoking.

AB - Increasing dopamine D(2/3) receptor availability is postulated to be a treatment for drug addiction. Varenicline, an alpha4beta2-nicotinic partial agonist, is effective for nicotine dependence. We hypothesize that varenicline increases dopamine D(2/3) receptor availability. Twenty male drug-naïve rats were randomized to varenicline (2 mg/kg) or placebo for 14 days, and then injected with the dopamine D(2/3) radiotracer 123I-IBZM. We found significantly higher striatum-to-cerebellum binding ratios in both dorsal and ventral striatum for the varenicline group compared with placebo. Varenicline increases dopamine D(2/3) receptor availability in drug-naïve rats. Therefore, varenicline may be an effective treatment for addictions other than smoking.

U2 - doi: 10.1111/j.1369-1600.2009.00168.x

DO - doi: 10.1111/j.1369-1600.2009.00168.x

M3 - Article

VL - 14

SP - 500

EP - 502

JO - Addiction Biology

JF - Addiction Biology

SN - 1355-6215

IS - 4

ER -

ID: 49996873