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Varenicline increases in-vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats. / Crunelle, Cleo; DE WIT, TC; de Bruin, K; Ramakers, Ruud M; van der Have, F; BEEKMAN, FJ; Van Den Brink, W.; Booij, J.

In: Nuclear Medicine & Biology, Vol. 39, No. 5, 2011, p. 640-644.

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Harvard

Crunelle, C, DE WIT, TC, de Bruin, K, Ramakers, RM, van der Have, F, BEEKMAN, FJ, Van Den Brink, W & Booij, J 2011, 'Varenicline increases in-vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats.', Nuclear Medicine & Biology, vol. 39, no. 5, pp. 640-644. https://doi.org/doi: 10.1016/j.nucmedbio.2011.11.006

APA

Crunelle, C., DE WIT, TC., de Bruin, K., Ramakers, R. M., van der Have, F., BEEKMAN, FJ., ... Booij, J. (2011). Varenicline increases in-vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats. Nuclear Medicine & Biology, 39(5), 640-644. https://doi.org/doi: 10.1016/j.nucmedbio.2011.11.006

Vancouver

Author

Crunelle, Cleo ; DE WIT, TC ; de Bruin, K ; Ramakers, Ruud M ; van der Have, F ; BEEKMAN, FJ ; Van Den Brink, W. ; Booij, J. / Varenicline increases in-vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats. In: Nuclear Medicine & Biology. 2011 ; Vol. 39, No. 5. pp. 640-644.

BibTeX

@article{4da5924344684bc6bbe35ae456c66356,
title = "Varenicline increases in-vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats.",
abstract = "INTRODUCTION: Ex vivo storage phosphor imaging rat studies reported increased brain dopamine D2/3 receptor (DRD2/3) availability following treatment with varenicline, a nicotinergic drug. However, ex vivo studies can only be performed using cross-sectional designs. Small-animal imaging offers the opportunity to perform serial assessments. We evaluated whether high-resolution pinhole single photon emission computed tomography (SPECT) imaging in rats was able to reproduce previous ex vivo findings.METHODS: Rats were imaged for baseline striatal DRD2/3 availability using ultra-high-resolution pinhole SPECT (U-SPECT-II) and [123I]IBZM as a radiotracer, and randomized to varenicline (n=7; 2 mg/kg) or saline (n=7). Following 2 weeks of treatment, a second scan was acquired.RESULTS: Significantly increased striatal DRD2/3 availability was found following varenicline treatment compared to saline (time⁎treatment effect): posttreatment difference in binding potential between groups corrected for initial baseline differences was 2.039 (P=.022), indicating a large effect size (d=1.48).CONCLUSIONS: Ultra-high-resolution pinhole SPECT can be used to assess varenicline-induced changes in DRD2/3 availability in small laboratory animals over time. Future small-animal studies should include imaging techniques to enable repeated within-subjects measurements and reduce the amount of animals.",
author = "Cleo Crunelle and {DE WIT}, TC and {de Bruin}, K and Ramakers, {Ruud M} and {van der Have}, F and FJ BEEKMAN and {Van Den Brink}, W. and J Booij",
year = "2011",
doi = "doi: 10.1016/j.nucmedbio.2011.11.006",
language = "English",
volume = "39",
pages = "640--644",
journal = "Nuclear Medicine and Biology",
issn = "0969-8051",
publisher = "Elsevier Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Varenicline increases in-vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats.

AU - Crunelle, Cleo

AU - DE WIT, TC

AU - de Bruin, K

AU - Ramakers, Ruud M

AU - van der Have, F

AU - BEEKMAN, FJ

AU - Van Den Brink, W.

AU - Booij, J

PY - 2011

Y1 - 2011

N2 - INTRODUCTION: Ex vivo storage phosphor imaging rat studies reported increased brain dopamine D2/3 receptor (DRD2/3) availability following treatment with varenicline, a nicotinergic drug. However, ex vivo studies can only be performed using cross-sectional designs. Small-animal imaging offers the opportunity to perform serial assessments. We evaluated whether high-resolution pinhole single photon emission computed tomography (SPECT) imaging in rats was able to reproduce previous ex vivo findings.METHODS: Rats were imaged for baseline striatal DRD2/3 availability using ultra-high-resolution pinhole SPECT (U-SPECT-II) and [123I]IBZM as a radiotracer, and randomized to varenicline (n=7; 2 mg/kg) or saline (n=7). Following 2 weeks of treatment, a second scan was acquired.RESULTS: Significantly increased striatal DRD2/3 availability was found following varenicline treatment compared to saline (time⁎treatment effect): posttreatment difference in binding potential between groups corrected for initial baseline differences was 2.039 (P=.022), indicating a large effect size (d=1.48).CONCLUSIONS: Ultra-high-resolution pinhole SPECT can be used to assess varenicline-induced changes in DRD2/3 availability in small laboratory animals over time. Future small-animal studies should include imaging techniques to enable repeated within-subjects measurements and reduce the amount of animals.

AB - INTRODUCTION: Ex vivo storage phosphor imaging rat studies reported increased brain dopamine D2/3 receptor (DRD2/3) availability following treatment with varenicline, a nicotinergic drug. However, ex vivo studies can only be performed using cross-sectional designs. Small-animal imaging offers the opportunity to perform serial assessments. We evaluated whether high-resolution pinhole single photon emission computed tomography (SPECT) imaging in rats was able to reproduce previous ex vivo findings.METHODS: Rats were imaged for baseline striatal DRD2/3 availability using ultra-high-resolution pinhole SPECT (U-SPECT-II) and [123I]IBZM as a radiotracer, and randomized to varenicline (n=7; 2 mg/kg) or saline (n=7). Following 2 weeks of treatment, a second scan was acquired.RESULTS: Significantly increased striatal DRD2/3 availability was found following varenicline treatment compared to saline (time⁎treatment effect): posttreatment difference in binding potential between groups corrected for initial baseline differences was 2.039 (P=.022), indicating a large effect size (d=1.48).CONCLUSIONS: Ultra-high-resolution pinhole SPECT can be used to assess varenicline-induced changes in DRD2/3 availability in small laboratory animals over time. Future small-animal studies should include imaging techniques to enable repeated within-subjects measurements and reduce the amount of animals.

U2 - doi: 10.1016/j.nucmedbio.2011.11.006

DO - doi: 10.1016/j.nucmedbio.2011.11.006

M3 - Article

VL - 39

SP - 640

EP - 644

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

SN - 0969-8051

IS - 5

ER -

ID: 49996315