This study examined possible interactions between immunological abnormalities and symptoms in CFS. Sixteen CFS patients filled in a battery of questionnaires, evaluating daily functioning, and underwent venous blood sampling, in order to analyse immunological abnormalities. Ribonuclease (RNase) L cleavage was associated with RNase L activity (rs=0.570; p=0.021), protein kinase R (PKR) (rs=0.716; p=0.002) and elastase activity (rs=0.500; p=0.049). RNase L activity was related to elastase (rs=0.547; p=0.028) and PKR activity (rs=0.625; p=0.010). RNase L activity (rs=0.535; p=0.033), elastase activity (rs=0.585; p=0.017) and RNase L cleavage (rs=0.521; p=0.038) correlated with daily functioning. This study suggests that in CFS patients an increase in elastase activity and subsequent RNase L cleavage is accompanied by increased activity of both the PKR and RNase L enzymes. RNase L and elastase activity are related to daily functioning, thus evidence supporting the clinical importance of these immune dysfunctions in CFS patients was provided.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalIn Vivo
Volume22
Issue number1
Publication statusPublished - 10 Apr 2008

    Research areas

  • Adolescent, Adult, Aged, Disability Evaluation, Endoribonucleases, Fatigue Syndrome, Chronic, Female, Health Status, Humans, Immune System, Lymphocytes, Male, Middle Aged, Monocytes, Pancreatic Elastase, Quality of Life, Surveys and Questionnaires, eIF-2 Kinase, Journal Article

ID: 36914495