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TOP 15 RESEARCH PRIORITIES IN TUBEROUS SCLEROSIS COMPLEX. / Jansen, A. C.; Schoeters, E.; Wouters, A.; T'Seyen, A.; Gombault, B.; Raeymaekers, P.

In: Journal of Intellectual Disability Research, Vol. 50, No. 5, 12.07.2018, p. 668-681.

Research output: Contribution to journalMeeting abstract (Journal)

Harvard

Jansen, AC, Schoeters, E, Wouters, A, T'Seyen, A, Gombault, B & Raeymaekers, P 2018, 'TOP 15 RESEARCH PRIORITIES IN TUBEROUS SCLEROSIS COMPLEX', Journal of Intellectual Disability Research, vol. 50, no. 5, pp. 668-681. https://doi.org/10.1038/s41588-018-0090-3

APA

Jansen, A. C., Schoeters, E., Wouters, A., T'Seyen, A., Gombault, B., & Raeymaekers, P. (2018). TOP 15 RESEARCH PRIORITIES IN TUBEROUS SCLEROSIS COMPLEX. Journal of Intellectual Disability Research, 50(5), 668-681. https://doi.org/10.1038/s41588-018-0090-3

Vancouver

Jansen AC, Schoeters E, Wouters A, T'Seyen A, Gombault B, Raeymaekers P. TOP 15 RESEARCH PRIORITIES IN TUBEROUS SCLEROSIS COMPLEX. Journal of Intellectual Disability Research. 2018 Jul 12;50(5):668-681. https://doi.org/10.1038/s41588-018-0090-3

Author

Jansen, A. C. ; Schoeters, E. ; Wouters, A. ; T'Seyen, A. ; Gombault, B. ; Raeymaekers, P. / TOP 15 RESEARCH PRIORITIES IN TUBEROUS SCLEROSIS COMPLEX. In: Journal of Intellectual Disability Research. 2018 ; Vol. 50, No. 5. pp. 668-681.

BibTeX

@article{3c841626e2a946ce96640eb3b21e6235,
title = "TOP 15 RESEARCH PRIORITIES IN TUBEROUS SCLEROSIS COMPLEX",
abstract = "Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.",
keywords = "multi-stakeholder dialogue, research priority setting, stakeholder participation, tuberous sclerosis complex",
author = "Jansen, {A. C.} and E. Schoeters and A. Wouters and A. T'Seyen and B. Gombault and P. Raeymaekers",
year = "2018",
month = "7",
day = "12",
doi = "10.1038/s41588-018-0090-3",
language = "English",
volume = "50",
pages = "668--681",
journal = "Journal of Intellectual Disability Research",
issn = "0964-2633",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - TOP 15 RESEARCH PRIORITIES IN TUBEROUS SCLEROSIS COMPLEX

AU - Jansen, A. C.

AU - Schoeters, E.

AU - Wouters, A.

AU - T'Seyen, A.

AU - Gombault, B.

AU - Raeymaekers, P.

PY - 2018/7/12

Y1 - 2018/7/12

N2 - Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.

AB - Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.

KW - multi-stakeholder dialogue

KW - research priority setting

KW - stakeholder participation

KW - tuberous sclerosis complex

UR - http://www.scopus.com/inward/record.url?scp=85046022254&partnerID=8YFLogxK

UR - https://cristest.vub.be/en/publications/top-15-research-priorities-in-tuberous-sclerosis-complex(3c841626-e2a9-46ce-9664-0eb3b21e6235).html

U2 - 10.1038/s41588-018-0090-3

DO - 10.1038/s41588-018-0090-3

M3 - Meeting abstract (Journal)

VL - 50

SP - 668

EP - 681

JO - Journal of Intellectual Disability Research

JF - Journal of Intellectual Disability Research

SN - 0964-2633

IS - 5

ER -

ID: 39967362