• A. C. Jansen
  • E. Schoeters
  • A. Wouters
  • A. T'Seyen
  • B. Gombault
  • P. Raeymaekers

Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.

Original languageEnglish
Pages (from-to)668-681
Number of pages14
JournalJournal of Intellectual Disability Research
Volume50
Issue number5
DOIs
Publication statusPublished - 12 Jul 2018

    Research areas

  • multi-stakeholder dialogue, research priority setting, stakeholder participation, tuberous sclerosis complex

ID: 39967362