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The influence of one session of low frequency rTMS on pre-supplementary motor area metabolites in late stage Parkinson's disease. / Flamez, Anja; Wiels, Wietse; Van Schuerbeek, Peter; De Mey, Johan; De Keyser, Jacques; Baeken, Chris.

In: Clinical Neurophysiology, Vol. 130, No. 8, 01.08.2019, p. 1292-1298.

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@article{377a1c79f4df4b499061b66ee28c2ef7,
title = "The influence of one session of low frequency rTMS on pre-supplementary motor area metabolites in late stage Parkinson's disease",
abstract = "OBJECTIVE: To study the effect of Low Frequency repetitive Transcranial Magnetic Stimulation (LF rTMS) on brain metabolites in late stage Parkinson's disease (PD) patients (disease duration at least 4 years and Hoehn and Yahr (1969) score at least 2 in OFF). Several neuroimaging data support a role for pre-Supplementary Motor Area (pre-SMA) involvement in the pathogenesis of Parkinson's disease. Proton magnetic resonance spectroscopy (1H-MRS) measures in vivo metabolites, but results in PD brain remain conflicting and little is known of the effect of LF rTMS thereupon.METHODS: We investigate the neurochemical profile of the right pre-SMA in 17 late stage PD patients (11 male and 6 female, mean age of 71 years) before and after one session of sham controlled 1 Hz rTMS (1000 pulses, 16 minutes), focusing on the tNAA/tCr and tCho/tCr ratios.RESULTS: The tNAA/tCr ratio was unaffected by one session of LF rTMS. We did observe a significant effect of real LF rTMS on the tCho/tCr ratio, inversely correlated with disease duration, and not related to the presence of dyskinesias. As expected, one session of LF rTMS did not affect clinical outcome.CONCLUSIONS: LF rTMS at the right pre-SMA in late stage Parkinson's disease patients does not alter tNAA/tCr, but influences tCho/tCr ratio, in particular in patients with shorter disease duration.SIGNIFICANCE: Pre-SMA LF rTMS seems to influence membrane turnover, more importantly in patients with shorter disease duration. Larger LF rTMS treatment studies applying multiple sessions are needed.",
keywords = "Dyskinesias, Parkinson's disease, Spectroscopy, rTMS",
author = "Anja Flamez and Wietse Wiels and {Van Schuerbeek}, Peter and {De Mey}, Johan and {De Keyser}, Jacques and Chris Baeken",
note = "Copyright {\circledC} 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.",
year = "2019",
month = "8",
day = "1",
doi = "10.1016/j.clinph.2019.04.720",
language = "English",
volume = "130",
pages = "1292--1298",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - The influence of one session of low frequency rTMS on pre-supplementary motor area metabolites in late stage Parkinson's disease

AU - Flamez, Anja

AU - Wiels, Wietse

AU - Van Schuerbeek, Peter

AU - De Mey, Johan

AU - De Keyser, Jacques

AU - Baeken, Chris

N1 - Copyright © 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - OBJECTIVE: To study the effect of Low Frequency repetitive Transcranial Magnetic Stimulation (LF rTMS) on brain metabolites in late stage Parkinson's disease (PD) patients (disease duration at least 4 years and Hoehn and Yahr (1969) score at least 2 in OFF). Several neuroimaging data support a role for pre-Supplementary Motor Area (pre-SMA) involvement in the pathogenesis of Parkinson's disease. Proton magnetic resonance spectroscopy (1H-MRS) measures in vivo metabolites, but results in PD brain remain conflicting and little is known of the effect of LF rTMS thereupon.METHODS: We investigate the neurochemical profile of the right pre-SMA in 17 late stage PD patients (11 male and 6 female, mean age of 71 years) before and after one session of sham controlled 1 Hz rTMS (1000 pulses, 16 minutes), focusing on the tNAA/tCr and tCho/tCr ratios.RESULTS: The tNAA/tCr ratio was unaffected by one session of LF rTMS. We did observe a significant effect of real LF rTMS on the tCho/tCr ratio, inversely correlated with disease duration, and not related to the presence of dyskinesias. As expected, one session of LF rTMS did not affect clinical outcome.CONCLUSIONS: LF rTMS at the right pre-SMA in late stage Parkinson's disease patients does not alter tNAA/tCr, but influences tCho/tCr ratio, in particular in patients with shorter disease duration.SIGNIFICANCE: Pre-SMA LF rTMS seems to influence membrane turnover, more importantly in patients with shorter disease duration. Larger LF rTMS treatment studies applying multiple sessions are needed.

AB - OBJECTIVE: To study the effect of Low Frequency repetitive Transcranial Magnetic Stimulation (LF rTMS) on brain metabolites in late stage Parkinson's disease (PD) patients (disease duration at least 4 years and Hoehn and Yahr (1969) score at least 2 in OFF). Several neuroimaging data support a role for pre-Supplementary Motor Area (pre-SMA) involvement in the pathogenesis of Parkinson's disease. Proton magnetic resonance spectroscopy (1H-MRS) measures in vivo metabolites, but results in PD brain remain conflicting and little is known of the effect of LF rTMS thereupon.METHODS: We investigate the neurochemical profile of the right pre-SMA in 17 late stage PD patients (11 male and 6 female, mean age of 71 years) before and after one session of sham controlled 1 Hz rTMS (1000 pulses, 16 minutes), focusing on the tNAA/tCr and tCho/tCr ratios.RESULTS: The tNAA/tCr ratio was unaffected by one session of LF rTMS. We did observe a significant effect of real LF rTMS on the tCho/tCr ratio, inversely correlated with disease duration, and not related to the presence of dyskinesias. As expected, one session of LF rTMS did not affect clinical outcome.CONCLUSIONS: LF rTMS at the right pre-SMA in late stage Parkinson's disease patients does not alter tNAA/tCr, but influences tCho/tCr ratio, in particular in patients with shorter disease duration.SIGNIFICANCE: Pre-SMA LF rTMS seems to influence membrane turnover, more importantly in patients with shorter disease duration. Larger LF rTMS treatment studies applying multiple sessions are needed.

KW - Dyskinesias

KW - Parkinson's disease

KW - Spectroscopy

KW - rTMS

UR - http://www.scopus.com/inward/record.url?scp=85066751578&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2019.04.720

DO - 10.1016/j.clinph.2019.04.720

M3 - Article

VL - 130

SP - 1292

EP - 1298

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 8

ER -

ID: 46018655