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The Impact of Cognitive Dysfunction on Locomotor Rehabilitation Potential in Multiple Sclerosis. / Denissen, Stijn; Cock, Alexander De; Meurrens, Tom; Vleugels, Luc; Remoortel, Ann Van; Gebara, Benoit; D’Haeseleer, Miguel; D’Hooghe, Marie B; Schependom, Jeroen Van; Nagels, Guy.

In: Journal of central nervous system disease, Vol. 11, 06.11.2019, p. 1-5.

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@article{95db870186d4453db287b2585a801a11,
title = "The Impact of Cognitive Dysfunction on Locomotor Rehabilitation Potential in Multiple Sclerosis",
abstract = "Background: Cognitive dysfunction is a frequent manifestation of multiple sclerosis (MS) but its effect on locomotor rehabilitation is unknown.Objective: To study the impact of cognitive impairment on locomotor rehabilitation outcome in people with MS.Methods: We performed a retrospective analysis involving ambulatory patients with MS who were admitted for intensive, inpatient, multidisciplinary rehabilitation at the National Multiple Sclerosis Center of Melsbroek between the years 2012 and 2017. The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) was used to determine the cognitive status of subjects as either impaired (COG-) or preserved (COG+). Locomotor outcome was compared between groups with the difference in 6-minute walk test (6MWT) measured at admission and discharge (Δ6MWT). In addition, individual test scores of the BRB-N for attention (Paced Auditory Serial Addition Test 2{"} and 3{"}), visuospatial learning/memory (7/24 Spatial Recall Test), verbal learning/memory (Selective Reminding Test) and verbal fluency (Controlled Oral Word Association Test) were correlated to the Δ6MWT.Results: A total of 318 complete and unique records were identified. Both groups showed a significant within-group Δ6MWT during hospitalization (COG+: 47.51 m; COG-: 40.97 m; P  < .01). In contrast, Δ6MWT values were comparable between groups. The odds of achieving a minimal clinical important difference on the 6MWT did not differ significantly between both groups. Only attention/concentration was significantly correlated with Δ6MWT (r = 0.16, P  = .013). Conclusion: Cognitive impairment based on BRB-N results appears not to impede locomotor rehabilitation in ambulatory patients with MS. Attentional deficits are correlated to the extent of locomotor rehabilitation, suggesting the presence of a subtle effect of cognition.",
keywords = "Multiple Sclerosis, Walking, Cognitive Impairment, Multidisciplinary Rehabilitation",
author = "Stijn Denissen and Cock, {Alexander De} and Tom Meurrens and Luc Vleugels and Remoortel, {Ann Van} and Benoit Gebara and Miguel D’Haeseleer and D’Hooghe, {Marie B} and Schependom, {Jeroen Van} and Guy Nagels",
note = "{\circledC} The Author(s) 2019.",
year = "2019",
month = "11",
day = "6",
doi = "10.1177/1179573519884041",
language = "English",
volume = "11",
pages = "1--5",
journal = "Journal of central nervous system disease",
issn = "1179-5735",
publisher = "Libertas Academica",

}

RIS

TY - JOUR

T1 - The Impact of Cognitive Dysfunction on Locomotor Rehabilitation Potential in Multiple Sclerosis

AU - Denissen, Stijn

AU - Cock, Alexander De

AU - Meurrens, Tom

AU - Vleugels, Luc

AU - Remoortel, Ann Van

AU - Gebara, Benoit

AU - D’Haeseleer, Miguel

AU - D’Hooghe, Marie B

AU - Schependom, Jeroen Van

AU - Nagels, Guy

N1 - © The Author(s) 2019.

PY - 2019/11/6

Y1 - 2019/11/6

N2 - Background: Cognitive dysfunction is a frequent manifestation of multiple sclerosis (MS) but its effect on locomotor rehabilitation is unknown.Objective: To study the impact of cognitive impairment on locomotor rehabilitation outcome in people with MS.Methods: We performed a retrospective analysis involving ambulatory patients with MS who were admitted for intensive, inpatient, multidisciplinary rehabilitation at the National Multiple Sclerosis Center of Melsbroek between the years 2012 and 2017. The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) was used to determine the cognitive status of subjects as either impaired (COG-) or preserved (COG+). Locomotor outcome was compared between groups with the difference in 6-minute walk test (6MWT) measured at admission and discharge (Δ6MWT). In addition, individual test scores of the BRB-N for attention (Paced Auditory Serial Addition Test 2" and 3"), visuospatial learning/memory (7/24 Spatial Recall Test), verbal learning/memory (Selective Reminding Test) and verbal fluency (Controlled Oral Word Association Test) were correlated to the Δ6MWT.Results: A total of 318 complete and unique records were identified. Both groups showed a significant within-group Δ6MWT during hospitalization (COG+: 47.51 m; COG-: 40.97 m; P  < .01). In contrast, Δ6MWT values were comparable between groups. The odds of achieving a minimal clinical important difference on the 6MWT did not differ significantly between both groups. Only attention/concentration was significantly correlated with Δ6MWT (r = 0.16, P  = .013). Conclusion: Cognitive impairment based on BRB-N results appears not to impede locomotor rehabilitation in ambulatory patients with MS. Attentional deficits are correlated to the extent of locomotor rehabilitation, suggesting the presence of a subtle effect of cognition.

AB - Background: Cognitive dysfunction is a frequent manifestation of multiple sclerosis (MS) but its effect on locomotor rehabilitation is unknown.Objective: To study the impact of cognitive impairment on locomotor rehabilitation outcome in people with MS.Methods: We performed a retrospective analysis involving ambulatory patients with MS who were admitted for intensive, inpatient, multidisciplinary rehabilitation at the National Multiple Sclerosis Center of Melsbroek between the years 2012 and 2017. The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) was used to determine the cognitive status of subjects as either impaired (COG-) or preserved (COG+). Locomotor outcome was compared between groups with the difference in 6-minute walk test (6MWT) measured at admission and discharge (Δ6MWT). In addition, individual test scores of the BRB-N for attention (Paced Auditory Serial Addition Test 2" and 3"), visuospatial learning/memory (7/24 Spatial Recall Test), verbal learning/memory (Selective Reminding Test) and verbal fluency (Controlled Oral Word Association Test) were correlated to the Δ6MWT.Results: A total of 318 complete and unique records were identified. Both groups showed a significant within-group Δ6MWT during hospitalization (COG+: 47.51 m; COG-: 40.97 m; P  < .01). In contrast, Δ6MWT values were comparable between groups. The odds of achieving a minimal clinical important difference on the 6MWT did not differ significantly between both groups. Only attention/concentration was significantly correlated with Δ6MWT (r = 0.16, P  = .013). Conclusion: Cognitive impairment based on BRB-N results appears not to impede locomotor rehabilitation in ambulatory patients with MS. Attentional deficits are correlated to the extent of locomotor rehabilitation, suggesting the presence of a subtle effect of cognition.

KW - Multiple Sclerosis

KW - Walking

KW - Cognitive Impairment

KW - Multidisciplinary Rehabilitation

UR - https://doi.org/10.1177/1179573519884041

U2 - 10.1177/1179573519884041

DO - 10.1177/1179573519884041

M3 - Article

C2 - 31723322

VL - 11

SP - 1

EP - 5

JO - Journal of central nervous system disease

JF - Journal of central nervous system disease

SN - 1179-5735

ER -

ID: 48104795