Background: Cognitive dysfunction is a frequent manifestation of multiple sclerosis (MS) but its effect on locomotor rehabilitation is unknown. Objective: To study the impact of cognitive impairment on locomotor rehabilitation outcome in patients with MS. Methods: We performed a retrospective analysis involving ambulatory patients with MS who were admitted for intensive, inpatient, multidisciplinary rehabilitation at the National Multiple Sclerosis Center of Melsbroek between the year 2012 and 2017. The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was used to determine the cognitive status of subjects as either impaired (COG-) or preserved (COG+). Locomotor outcome was compared between both groups by means of the difference in 6 minute walk test (6MWT) measured at admission and discharge (Δ6MWT). Results: A total of 376 complete and unique records were identified. Both groups showed a significant within-group improvement of 6MWT results during hospitalization (COG+: 48.08m, p < 0.001; COG-: 42.25m, p < 0.001). In contrast, Δ6MWT values were comparable between both groups. The number of participants achieving a minimal clinical important difference on the 6MWT did not differ significantly between both groups. Conclusion: Cognitive impairment based on BRB-N results does not seem to impede locomotor rehabilitation outcome in ambulatory patients with MS.
Original languageEnglish
Publication statusPublished - 1 Jun 2019

    Research areas

  • Multiple Sclerosis, Cognition, Locomotion, Rehabilitation

ID: 47095485