Chronic pain in breast cancer survivors(BCS) is of a considerable concern as it impacts the health-related quality of life(HRQoL) and activities of daily living negatively. Over the past decades, awareness has raised on the value of pain neuroscience education(PNE) in chronic pain. However, pain education remains underused in oncology and is often restricted to the biomedical management, which falls short in explaining persistent pain following cancer. Since PNE alone has rather small effect sizes, it should ideally be combined with a physical part, ‘behavioural graded activity’(BGA). Therefore, the purpose of this study is to investigate the effectiveness of PNE with BGA compared to usual care on chronic pain in BCS.
A two-arm, double-blinded trial will be conducted in which 200 BCS with persistent pain will be randomly assigned to the intervention or usual care group. The intervention group will receive a 12-week treatment program that consists of 6 sessions, in which PNE and BGA will be integrated. Whereas, the usual care group will receive an information leaflet regarding “Pain in and after cancer”. The primary outcome is pain, the secondary outcomes are endogenous hyperalgesia and HRQoL and the explanatory outcomes are mediators that might impact pain intensity of participants. All these will be assessed at baseline, immediate, 3 and 12 months post-treatment.
Hypotheses and possible implications
We hypothesise that PNE and BGA will lead to more beneficial pain outcomes compared to usual care in BCS with persistent pain. If so, it might lead to a treatment optimization of chronic pain in BCS.
Original languageEnglish
Publication statusUnpublished - 5 Mar 2020
EventBelgian Pain Society 1st Young Researchers Day - UCLouvain, Brussels, Belgium
Duration: 5 Mar 2020 → …


ConferenceBelgian Pain Society 1st Young Researchers Day
Abbreviated titleBPS-YRD
Period5/03/20 → …
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ID: 51418131