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The effect of nicotine patches on craving in the brain : A functional MRI study on heavy smokers. / Liberman, Keliane; Van Schuerbeek, Peter; Herremans, Sarah; Meysman, Marc; De Mey, Johan; Buls, Nico.

In: Medicine, Vol. 97, No. 39, e12415, 09.2018.

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@article{32e04461a8884cb3a30fbd0594222a44,
title = "The effect of nicotine patches on craving in the brain: A functional MRI study on heavy smokers",
abstract = "BACKGROUND: Smoking is a common phenomenon and kills over 6 million people every year. Many smokers try to quit smoking by using nicotine replacement therapy (NRT). Most of the time, relapse occurs in less than six months after finishing the program of NRT. We performed a single blinded study in which our aim was to figure out what the effect of the nicotine patch is on craving in the brain of smokers deprived from smoking.METHODS: Five heavy smokers (Fagerstr{\"o}m Test for Nicotine Dependence ≥4) underwent a functional magnetic resonance imaging (fMRI) in 4 random conditions: smoking (S); smoking deprivation (SD); SD combined with a NP (SD + NP); SD combined with a placebo patch (SD + PP). Visual stimulation provoked craving in block design by randomly displaying images of smoking related scenes. After image preprocessing, a fixed-effect analysis was performed to compare average group activations. The Questionnaire for Smoking Urges (QSU) was obtained before and after each scan.RESULTS: The fMRI results showed higher activation in areas involved in craving in S compared with SD + NP, SD + PP, and SD. In the SD + NP, limbic circuit and attention area were higher activated compared with SD and SD + PP. The SD + PP and SD showed higher activation in the frontal cortex and limbic system compared with S and SD + NP. Nonsmokers showed higher limbic activation compared with SD.The QSU increased significantly after the fMRI experiment in S (P = .036).The SD had higher QSU scores compared with the S before (P = .002), and also after (P = .022) the fMRI experiment. The NP showed lower scores than the SD before the experiment (P = .046).CONCLUSION: The fMRI experiment revealed lower activity in areas associated with attention when subjects were nicotine deprived (SD + PP and SD). Areas involved with craving showed less activity when nicotine is present (S and SD + NP). The QSU showed a significant difference between SD and when nicotine is present (S and SD + NP).",
keywords = "Adult, Brain, Craving, Female, Humans, Magnetic Resonance Imaging, Male, Single-Blind Method, Smokers, Smoking, Tobacco Use Cessation Products, Tobacco Use Disorder, Journal Article, Randomized Controlled Trial",
author = "Keliane Liberman and {Van Schuerbeek}, Peter and Sarah Herremans and Marc Meysman and {De Mey}, Johan and Nico Buls",
year = "2018",
month = "9",
doi = "10.1097/MD.0000000000012415",
language = "English",
volume = "97",
journal = "Medicine",
issn = "0025-7974",
publisher = "Lippincott, Williams & Wilkins",
number = "39",

}

RIS

TY - JOUR

T1 - The effect of nicotine patches on craving in the brain

T2 - A functional MRI study on heavy smokers

AU - Liberman, Keliane

AU - Van Schuerbeek, Peter

AU - Herremans, Sarah

AU - Meysman, Marc

AU - De Mey, Johan

AU - Buls, Nico

PY - 2018/9

Y1 - 2018/9

N2 - BACKGROUND: Smoking is a common phenomenon and kills over 6 million people every year. Many smokers try to quit smoking by using nicotine replacement therapy (NRT). Most of the time, relapse occurs in less than six months after finishing the program of NRT. We performed a single blinded study in which our aim was to figure out what the effect of the nicotine patch is on craving in the brain of smokers deprived from smoking.METHODS: Five heavy smokers (Fagerström Test for Nicotine Dependence ≥4) underwent a functional magnetic resonance imaging (fMRI) in 4 random conditions: smoking (S); smoking deprivation (SD); SD combined with a NP (SD + NP); SD combined with a placebo patch (SD + PP). Visual stimulation provoked craving in block design by randomly displaying images of smoking related scenes. After image preprocessing, a fixed-effect analysis was performed to compare average group activations. The Questionnaire for Smoking Urges (QSU) was obtained before and after each scan.RESULTS: The fMRI results showed higher activation in areas involved in craving in S compared with SD + NP, SD + PP, and SD. In the SD + NP, limbic circuit and attention area were higher activated compared with SD and SD + PP. The SD + PP and SD showed higher activation in the frontal cortex and limbic system compared with S and SD + NP. Nonsmokers showed higher limbic activation compared with SD.The QSU increased significantly after the fMRI experiment in S (P = .036).The SD had higher QSU scores compared with the S before (P = .002), and also after (P = .022) the fMRI experiment. The NP showed lower scores than the SD before the experiment (P = .046).CONCLUSION: The fMRI experiment revealed lower activity in areas associated with attention when subjects were nicotine deprived (SD + PP and SD). Areas involved with craving showed less activity when nicotine is present (S and SD + NP). The QSU showed a significant difference between SD and when nicotine is present (S and SD + NP).

AB - BACKGROUND: Smoking is a common phenomenon and kills over 6 million people every year. Many smokers try to quit smoking by using nicotine replacement therapy (NRT). Most of the time, relapse occurs in less than six months after finishing the program of NRT. We performed a single blinded study in which our aim was to figure out what the effect of the nicotine patch is on craving in the brain of smokers deprived from smoking.METHODS: Five heavy smokers (Fagerström Test for Nicotine Dependence ≥4) underwent a functional magnetic resonance imaging (fMRI) in 4 random conditions: smoking (S); smoking deprivation (SD); SD combined with a NP (SD + NP); SD combined with a placebo patch (SD + PP). Visual stimulation provoked craving in block design by randomly displaying images of smoking related scenes. After image preprocessing, a fixed-effect analysis was performed to compare average group activations. The Questionnaire for Smoking Urges (QSU) was obtained before and after each scan.RESULTS: The fMRI results showed higher activation in areas involved in craving in S compared with SD + NP, SD + PP, and SD. In the SD + NP, limbic circuit and attention area were higher activated compared with SD and SD + PP. The SD + PP and SD showed higher activation in the frontal cortex and limbic system compared with S and SD + NP. Nonsmokers showed higher limbic activation compared with SD.The QSU increased significantly after the fMRI experiment in S (P = .036).The SD had higher QSU scores compared with the S before (P = .002), and also after (P = .022) the fMRI experiment. The NP showed lower scores than the SD before the experiment (P = .046).CONCLUSION: The fMRI experiment revealed lower activity in areas associated with attention when subjects were nicotine deprived (SD + PP and SD). Areas involved with craving showed less activity when nicotine is present (S and SD + NP). The QSU showed a significant difference between SD and when nicotine is present (S and SD + NP).

KW - Adult

KW - Brain

KW - Craving

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Single-Blind Method

KW - Smokers

KW - Smoking

KW - Tobacco Use Cessation Products

KW - Tobacco Use Disorder

KW - Journal Article

KW - Randomized Controlled Trial

UR - http://www.scopus.com/inward/record.url?scp=85054414179&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000012415

DO - 10.1097/MD.0000000000012415

M3 - Article

VL - 97

JO - Medicine

JF - Medicine

SN - 0025-7974

IS - 39

M1 - e12415

ER -

ID: 40566129