BACKGROUND/OBJECTIVES: Fluoxetine and prucalopride might change phosphocreatine (PCr) levels via the cAMP-PKA pathway, an interesting target in the neurodegenerative mechanisms of MS.

METHODS: We conducted a two-center double-blind, placebo-controlled, randomized trial including 48 relapsing-remitting MS patients. Patients were randomized to receive placebo (n = 13), fluoxetine (n = 15), or prucalopride (n = 14) for 6 weeks. Proton (1H) and phosphorus (31P) magnetic resonance spectroscopy (MRS) as well as volumetric and perfusion MR imaging were performed at weeks 0, 2, and 6. Clinical and cognitive testing were evaluated at weeks 0 and 6.

RESULTS: No significant changes were observed for both 31P and 1H MRS indices. We found a significant effect on white matter volume and a trend towards an increase in grey matter and whole brain volume in the fluoxetine group at week 2; however, these effects were not sustained at week 6 for white matter and whole brain volume. Fluoxetine and prucalopride showed a positive effect on 9-HPT, depression, and fatigue scores.

CONCLUSION: Both fluoxetine and prucalopride had a symptomatic effect on upper limb function, fatigue, and depression, but this should be interpreted with caution. No effect of treatment was found on 31P and 1H MRS parameters, suggesting that these molecules do not influence the PCr metabolism.

Original languageEnglish
Pages (from-to)2614-2624
Number of pages11
JournalJournal of Neurology
Volume265
Issue number11
DOIs
Publication statusPublished - Nov 2018

    Research areas

  • Adult, Benzofurans/adverse effects, Brain/diagnostic imaging, Double-Blind Method, Female, Fluoxetine/adverse effects, Gray Matter/diagnostic imaging, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging, Neuroprotective Agents/adverse effects, Organ Size, Phosphocreatine/metabolism, Phosphorus Isotopes, Protons, Treatment Outcome, White Matter/diagnostic imaging, Multiple sclerosis, Fluoxetine, Phosphocreatine, Prucalopride, Magnetic resonance spectroscopy

ID: 44419413