The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)- acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl- 1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline- 5,10-diones are a new class of quinones, which have not been reported yet.
Original languageEnglish
Pages (from-to)5345-5353
Number of pages9
JournalTetrahedron
Volume64
Publication statusPublished - 18 Mar 2008

    Research areas

  • tetrahydroisoquinolines, naphthoquinones, naphthalene, benz[g]isoquinoline-3,5,10(2H)-triones

ID: 1714370