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Spontaneous mutation in the AgrRS two-component regulatory system of Cupriavidus metallidurans results in enhanced silver resistance. / Ali, Md Muntasir; Mijnendonckx, Kristel; Provoost, Ann; Janssen, Paul; Mergeay, Max; Leys, Natalie; Charlier, Daniel; Monsieurs, Pieter; Van Houdt, Rob.

In: Metallomics, Vol. 11, No. 11, 11.2019, p. 1912-1924.

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@article{d6d67388a8894f81a440f32e8fae99b4,
title = "Spontaneous mutation in the AgrRS two-component regulatory system of Cupriavidus metallidurans results in enhanced silver resistance",
abstract = "The uncontrolled and widespread use of (nano)silver compounds has led to the increased release of these compounds into the environment, raising concerns about their negative impact on ecosystems. Concomitantly, silver resistance determinants are widely spread among environmental and clinically relevant bacteria although the underlying mechanisms are not yet fully understood. We show that Cupriavidus metallidurans is able to adapt to toxic silver concentrations. However, none of the known silver resistance determinants present in C. metallidurans are involved in the adaptative response. Instead, increased silver resistance is achieved by the concerted action of a two-component system AgrR–AgrS, previously not associated with metal resistance, and two periplasmic proteins PrsQ1 and PrsQ2. Both proteins belong to an unique group of small, uncharacterized, secreted proteins restricted to the genera Cupriavidus and Ralstonia. This system gives C. metallidurans the ability to withstand much higher silver concentrations. The latter could be facilitated by the accumulation of silver ions and the formation of silver nanoparticles.",
keywords = "Silver, Nanoparticle, metal resistance, Cupriavidus metallidurans",
author = "Ali, {Md Muntasir} and Kristel Mijnendonckx and Ann Provoost and Paul Janssen and Max Mergeay and Natalie Leys and Daniel Charlier and Pieter Monsieurs and {Van Houdt}, Rob",
year = "2019",
month = "11",
doi = "10.1039/C9MT00123A",
language = "English",
volume = "11",
pages = "1912--1924",
journal = "Metallomics",
issn = "1756-5901",
publisher = "Royal Society of Chemistry",
number = "11",

}

RIS

TY - JOUR

T1 - Spontaneous mutation in the AgrRS two-component regulatory system of Cupriavidus metallidurans results in enhanced silver resistance

AU - Ali, Md Muntasir

AU - Mijnendonckx, Kristel

AU - Provoost, Ann

AU - Janssen, Paul

AU - Mergeay, Max

AU - Leys, Natalie

AU - Charlier, Daniel

AU - Monsieurs, Pieter

AU - Van Houdt, Rob

PY - 2019/11

Y1 - 2019/11

N2 - The uncontrolled and widespread use of (nano)silver compounds has led to the increased release of these compounds into the environment, raising concerns about their negative impact on ecosystems. Concomitantly, silver resistance determinants are widely spread among environmental and clinically relevant bacteria although the underlying mechanisms are not yet fully understood. We show that Cupriavidus metallidurans is able to adapt to toxic silver concentrations. However, none of the known silver resistance determinants present in C. metallidurans are involved in the adaptative response. Instead, increased silver resistance is achieved by the concerted action of a two-component system AgrR–AgrS, previously not associated with metal resistance, and two periplasmic proteins PrsQ1 and PrsQ2. Both proteins belong to an unique group of small, uncharacterized, secreted proteins restricted to the genera Cupriavidus and Ralstonia. This system gives C. metallidurans the ability to withstand much higher silver concentrations. The latter could be facilitated by the accumulation of silver ions and the formation of silver nanoparticles.

AB - The uncontrolled and widespread use of (nano)silver compounds has led to the increased release of these compounds into the environment, raising concerns about their negative impact on ecosystems. Concomitantly, silver resistance determinants are widely spread among environmental and clinically relevant bacteria although the underlying mechanisms are not yet fully understood. We show that Cupriavidus metallidurans is able to adapt to toxic silver concentrations. However, none of the known silver resistance determinants present in C. metallidurans are involved in the adaptative response. Instead, increased silver resistance is achieved by the concerted action of a two-component system AgrR–AgrS, previously not associated with metal resistance, and two periplasmic proteins PrsQ1 and PrsQ2. Both proteins belong to an unique group of small, uncharacterized, secreted proteins restricted to the genera Cupriavidus and Ralstonia. This system gives C. metallidurans the ability to withstand much higher silver concentrations. The latter could be facilitated by the accumulation of silver ions and the formation of silver nanoparticles.

KW - Silver

KW - Nanoparticle

KW - metal resistance

KW - Cupriavidus metallidurans

UR - http://www.scopus.com/inward/record.url?scp=85074965796&partnerID=8YFLogxK

U2 - 10.1039/C9MT00123A

DO - 10.1039/C9MT00123A

M3 - Article

VL - 11

SP - 1912

EP - 1924

JO - Metallomics

JF - Metallomics

SN - 1756-5901

IS - 11

ER -

ID: 47871916