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Serum progesterone levels could predict diagnosis, completion and complications of miscarriage. / Blavier, Frederic; Blockeel, Christophe; Cools, Wilfried; Faron, Gilles; Santos-Ribeiro, Samuel; Breugelmans, Maria; Adriaensen, Paul; Fuchs, Florent; Gucciardo, Leonardo.

In: Journal of Gynecology Obstetrics and Human Reproduction, Vol. 49, No. 5, 101721, 05.2020.

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@article{093491e21ad546b28f79f195a80806e2,
title = "Serum progesterone levels could predict diagnosis, completion and complications of miscarriage",
abstract = "BACKGROUND: Low serum progesterone levels were strongly correlated with miscarriages in several publications and with completion of miscarriage in one paper. This study evaluated several parameters, predominantly serum progesterone, as predictors for miscarriages, their swift non-surgical completion and their complications.BASIC PROCEDURES: Suspected or confirmed non-viable pregnancies with available concomitant serum progesterone measurements were retrospectively reviewed. The performance of serum progesterone, either alone or combined with other parameters, to predict viability, surgical removal and delay of non-surgical evacuation of non-viable pregnancy and complications, was analysed by logistic regression combined with Akaike and Bayesian information criteria, likelihood, receiver operated characteristic (ROC) curves, Mann-Whitney test and Fisher's exact test.MAIN FINDINGS: From 151 included pregnancies, 104 (68.9{\%}) were non-viable with 91 completions of miscarriage without surgery. The probability of viability was correlated linearly and curvilinearly with serum progesterone (p < 0.001). The probability of surgical removal, and the delay before non-surgical evacuation, showed a linear relationship with progesterone. No complication occurred when progesterone levels remained below 10 µg/L, while its rates were 9.5{\%} of non-viable pregnancies with progesterone levels between 10 and 20 µg/L and 26.7{\%} of cases with progesterone levels above 20 µg/L. Combined with progesterone, either {"}parity{"} or {"}history of miscarriage{"} improved the prediction of viability, {"}history of supra-isthmic uterine surgery{"} improved the prediction of surgery and {"}history of miscarriage{"} improved the prediction of delayed non-surgical evacuations.CONCLUSION: Serum progesterone can probably predict the odds of miscarriages, surgical removal, delayed non-surgical evacuation and complications, with potential improvements when different predictors are combined.",
keywords = "Progesterone, curettage, haemorrhage, infection, miscarriage, viability",
author = "Frederic Blavier and Christophe Blockeel and Wilfried Cools and Gilles Faron and Samuel Santos-Ribeiro and Maria Breugelmans and Paul Adriaensen and Florent Fuchs and Leonardo Gucciardo",
note = "Copyright {\circledC} 2020. Published by Elsevier Masson SAS.",
year = "2020",
month = "5",
doi = "10.1016/j.jogoh.2020.101721",
language = "English",
volume = "49",
journal = "Journal of Gynecology Obstetrics and Human Reproduction",
issn = "2468-7847",
publisher = "Elsevier Masson",
number = "5",

}

RIS

TY - JOUR

T1 - Serum progesterone levels could predict diagnosis, completion and complications of miscarriage

AU - Blavier, Frederic

AU - Blockeel, Christophe

AU - Cools, Wilfried

AU - Faron, Gilles

AU - Santos-Ribeiro, Samuel

AU - Breugelmans, Maria

AU - Adriaensen, Paul

AU - Fuchs, Florent

AU - Gucciardo, Leonardo

N1 - Copyright © 2020. Published by Elsevier Masson SAS.

PY - 2020/5

Y1 - 2020/5

N2 - BACKGROUND: Low serum progesterone levels were strongly correlated with miscarriages in several publications and with completion of miscarriage in one paper. This study evaluated several parameters, predominantly serum progesterone, as predictors for miscarriages, their swift non-surgical completion and their complications.BASIC PROCEDURES: Suspected or confirmed non-viable pregnancies with available concomitant serum progesterone measurements were retrospectively reviewed. The performance of serum progesterone, either alone or combined with other parameters, to predict viability, surgical removal and delay of non-surgical evacuation of non-viable pregnancy and complications, was analysed by logistic regression combined with Akaike and Bayesian information criteria, likelihood, receiver operated characteristic (ROC) curves, Mann-Whitney test and Fisher's exact test.MAIN FINDINGS: From 151 included pregnancies, 104 (68.9%) were non-viable with 91 completions of miscarriage without surgery. The probability of viability was correlated linearly and curvilinearly with serum progesterone (p < 0.001). The probability of surgical removal, and the delay before non-surgical evacuation, showed a linear relationship with progesterone. No complication occurred when progesterone levels remained below 10 µg/L, while its rates were 9.5% of non-viable pregnancies with progesterone levels between 10 and 20 µg/L and 26.7% of cases with progesterone levels above 20 µg/L. Combined with progesterone, either "parity" or "history of miscarriage" improved the prediction of viability, "history of supra-isthmic uterine surgery" improved the prediction of surgery and "history of miscarriage" improved the prediction of delayed non-surgical evacuations.CONCLUSION: Serum progesterone can probably predict the odds of miscarriages, surgical removal, delayed non-surgical evacuation and complications, with potential improvements when different predictors are combined.

AB - BACKGROUND: Low serum progesterone levels were strongly correlated with miscarriages in several publications and with completion of miscarriage in one paper. This study evaluated several parameters, predominantly serum progesterone, as predictors for miscarriages, their swift non-surgical completion and their complications.BASIC PROCEDURES: Suspected or confirmed non-viable pregnancies with available concomitant serum progesterone measurements were retrospectively reviewed. The performance of serum progesterone, either alone or combined with other parameters, to predict viability, surgical removal and delay of non-surgical evacuation of non-viable pregnancy and complications, was analysed by logistic regression combined with Akaike and Bayesian information criteria, likelihood, receiver operated characteristic (ROC) curves, Mann-Whitney test and Fisher's exact test.MAIN FINDINGS: From 151 included pregnancies, 104 (68.9%) were non-viable with 91 completions of miscarriage without surgery. The probability of viability was correlated linearly and curvilinearly with serum progesterone (p < 0.001). The probability of surgical removal, and the delay before non-surgical evacuation, showed a linear relationship with progesterone. No complication occurred when progesterone levels remained below 10 µg/L, while its rates were 9.5% of non-viable pregnancies with progesterone levels between 10 and 20 µg/L and 26.7% of cases with progesterone levels above 20 µg/L. Combined with progesterone, either "parity" or "history of miscarriage" improved the prediction of viability, "history of supra-isthmic uterine surgery" improved the prediction of surgery and "history of miscarriage" improved the prediction of delayed non-surgical evacuations.CONCLUSION: Serum progesterone can probably predict the odds of miscarriages, surgical removal, delayed non-surgical evacuation and complications, with potential improvements when different predictors are combined.

KW - Progesterone

KW - curettage

KW - haemorrhage

KW - infection

KW - miscarriage

KW - viability

UR - http://www.scopus.com/inward/record.url?scp=85080099600&partnerID=8YFLogxK

U2 - 10.1016/j.jogoh.2020.101721

DO - 10.1016/j.jogoh.2020.101721

M3 - Article

C2 - 32113000

VL - 49

JO - Journal of Gynecology Obstetrics and Human Reproduction

JF - Journal of Gynecology Obstetrics and Human Reproduction

SN - 2468-7847

IS - 5

M1 - 101721

ER -

ID: 49564794