Objective: To evaluate prehospital heart rate variability (HRV) as a pre-
dictor of stroke severity and short term clinical outcome.
Methods: HRV was reg istered during ambulance transportation of acute
ischemic stroke patients using a non-invasive, 2 lead ECG registration
device. Assessment included time domain, frequency domain, nonlinear
and time-frequency analysis.
Results: Patient characteristics are summarized in Table 1. Four patients
were treated with IV r tPA and one patient was treated as par t of a clinical
tr ial comparing IV rtPA with placebo. Disease and outcome characteristics
are summarized in Table 2. No correlation between HRV par ameters and
in hospital mortality could be demonstrated. Peak HF was found to cor-
relate significantly (p = 0.037) w ith the NIHSS score on admission.
Parameters inversely associated with the NIHSS score at 24 hours included
pVLF, aVLF and alpha2 (p = 0.037). Peak HF was positively associated
with the NIHSS score at 24 hours (p = 0.037). Peak VLF was inversely
associated with the mRS score at 90 days (p = 0.044).
Conclusion: The results of this preliminary study indicate that prehospital
HF and VLF are associated with stroke severity and outcome. Further
study is needed to evaluate this effect in a larger population.

Original languageEnglish
Pages (from-to)200
JournalInternational Journal of Stroke
Issue numberSI
Publication statusPublished - 2015
EventAnnual Conference of the European Stroke Organisation - Glasgow, United Kingdom
Duration: 17 Apr 201519 Apr 2015

    Research areas

  • acute stroke patients

ID: 14206217