Implicit motor sequence learning (IMSL) is affected in Parkinson disease (PD). Research in healthy young participants shows the potential for transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) to enhance IMSL. In PD, only null-effects have been reported to date.We determined concurrent, short-term and long-term effects of anodal tDCS over M1 on IMSL, as measured by the Serial Reaction Time (SRT) task, in persons with PD with mild cognitive impairment (MCI).Concurrent (anodal/sham tDCS intervention during the SRT-task), short-term (5- minutes post-intervention) and long-term (1-week post-intervention) effects on IMSL were evaluated in persons with idiopathic PD (Hoehn & Yahr stage II-III) with MCI. Results of 11 persons with PD (8 men, 3 women; mean age = 77.1 years; mean disease duration = 7.7 years) showed significant IMSL in the anodal (p=.016), but not in the sham tDCS condition (p=.937). Post-hoc analyses showed that IMSL reached statistical significance at 1-week post-intervention (p<.001).Anodal tDCS over M1 exerted beneficial effects on IMSL in persons with PD with MCI, in particular one week post-intervention. Our study is the first to report a positive effect of tDCS on IMSL in PD. Further research should include a larger, more cognitively diverse sample as well as additional follow-up periods.
Original languageEnglish
Publication statusPublished - 15 May 2020
EventSynapsium Dondrite Conference on Cognitive Neuroscience - (Virtual), Nijmegen, Netherlands
Duration: 16 May 202016 May 2020


ConferenceSynapsium Dondrite Conference on Cognitive Neuroscience

ID: 54066118