Standard

Performance evaluation of the prototype Abbott Alinity hq hematology analyzer. / Van der Beken, Yolien Anna; Van Dalem, Annelien; Van Moer, Guy; Segers, Eddy; Damiaens, Serge; Hoffmann, Johannes; Lakos, Gabriella; Jochmans, Kristin.

In: International Journal of Laboratory Hematology, Vol. 41, No. 4, 08.2019, p. 448-455.

Research output: Contribution to journalArticle

Harvard

Van der Beken, YA, Van Dalem, A, Van Moer, G, Segers, E, Damiaens, S, Hoffmann, J, Lakos, G & Jochmans, K 2019, 'Performance evaluation of the prototype Abbott Alinity hq hematology analyzer', International Journal of Laboratory Hematology, vol. 41, no. 4, pp. 448-455. https://doi.org/10.1111/ijlh.13020

APA

Van der Beken, Y. A., Van Dalem, A., Van Moer, G., Segers, E., Damiaens, S., Hoffmann, J., ... Jochmans, K. (2019). Performance evaluation of the prototype Abbott Alinity hq hematology analyzer. International Journal of Laboratory Hematology, 41(4), 448-455. https://doi.org/10.1111/ijlh.13020

Vancouver

Van der Beken YA, Van Dalem A, Van Moer G, Segers E, Damiaens S, Hoffmann J et al. Performance evaluation of the prototype Abbott Alinity hq hematology analyzer. International Journal of Laboratory Hematology. 2019 Aug;41(4):448-455. https://doi.org/10.1111/ijlh.13020

Author

Van der Beken, Yolien Anna ; Van Dalem, Annelien ; Van Moer, Guy ; Segers, Eddy ; Damiaens, Serge ; Hoffmann, Johannes ; Lakos, Gabriella ; Jochmans, Kristin. / Performance evaluation of the prototype Abbott Alinity hq hematology analyzer. In: International Journal of Laboratory Hematology. 2019 ; Vol. 41, No. 4. pp. 448-455.

BibTeX

@article{10c4d8e96c5c401388d7fab0df9cd44e,
title = "Performance evaluation of the prototype Abbott Alinity hq hematology analyzer",
abstract = "Introduction: The analytical and clinical performance as well as the workflow efficiency of the novel, prototype Alinity hq hematology analyzer was evaluated in the clinical laboratory of Universitair Ziekenhuis Brussel, Department of Hematology, Brussels, Belgium. Methods: Within-run and within-laboratory imprecision, linearity, and carryover were assessed using clinical blood samples and commercial blood products. Four hundred and seventeen samples were selected for method comparison with Abbott CELL-DYN Sapphire, and for flagging performance analysis in comparison with smear review and manual microscopic white blood cell (WBC) differential. Results: Within-run and within-laboratory imprecision verification demonstrated low {\%}CV for complete blood count and WBC differential results within the normal ranges (0.1{\%}-10.4{\%}), except for basophil granulocytes. The linearity of the analytical measuring ranges was verified for WBCs, red blood cells, hemoglobin, and platelets. Alinity hq results showed strong agreement with those of CELL-DYN Sapphire. Good correlation was demonstrated with manual WBC differential results, with negative bias for neutrophil (NEU) granulocytes, and positive bias for lymphocytes and monocytes. Blasts were detected with 75{\%} sensitivity and 96{\%} specificity at 1{\%} blast threshold, and 100{\%} sensitivity at 5{\%} blast threshold. Immature granulocyte detection was more sensitive (81{\%} vs 76{\%}, P = 0.086) and specific (88{\%} vs 78{\%}, P = 0.0002) than with CELL-DYN Sapphire. Nucleated red blood cell detection was more sensitive (89{\%} vs 63{\%}, P < 0.001) and just slightly less specific (96{\%} vs 99{\%}, P = 0.0067) than with CELL-DYN Sapphire. Re-run and reflex testing rates were lower with Alinity hq. Conclusion: The Alinity hq hematology analyzer is suitable for clinical use.",
keywords = "Abbott Alinity hq, automated hematology analyzer, complete blood count, performance evaluation",
author = "{Van der Beken}, {Yolien Anna} and {Van Dalem}, Annelien and {Van Moer}, Guy and Eddy Segers and Serge Damiaens and Johannes Hoffmann and Gabriella Lakos and Kristin Jochmans",
year = "2019",
month = "8",
doi = "10.1111/ijlh.13020",
language = "English",
volume = "41",
pages = "448--455",
journal = "International Journal of Laboratory Hematology",
issn = "1751-5521",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Performance evaluation of the prototype Abbott Alinity hq hematology analyzer

AU - Van der Beken, Yolien Anna

AU - Van Dalem, Annelien

AU - Van Moer, Guy

AU - Segers, Eddy

AU - Damiaens, Serge

AU - Hoffmann, Johannes

AU - Lakos, Gabriella

AU - Jochmans, Kristin

PY - 2019/8

Y1 - 2019/8

N2 - Introduction: The analytical and clinical performance as well as the workflow efficiency of the novel, prototype Alinity hq hematology analyzer was evaluated in the clinical laboratory of Universitair Ziekenhuis Brussel, Department of Hematology, Brussels, Belgium. Methods: Within-run and within-laboratory imprecision, linearity, and carryover were assessed using clinical blood samples and commercial blood products. Four hundred and seventeen samples were selected for method comparison with Abbott CELL-DYN Sapphire, and for flagging performance analysis in comparison with smear review and manual microscopic white blood cell (WBC) differential. Results: Within-run and within-laboratory imprecision verification demonstrated low %CV for complete blood count and WBC differential results within the normal ranges (0.1%-10.4%), except for basophil granulocytes. The linearity of the analytical measuring ranges was verified for WBCs, red blood cells, hemoglobin, and platelets. Alinity hq results showed strong agreement with those of CELL-DYN Sapphire. Good correlation was demonstrated with manual WBC differential results, with negative bias for neutrophil (NEU) granulocytes, and positive bias for lymphocytes and monocytes. Blasts were detected with 75% sensitivity and 96% specificity at 1% blast threshold, and 100% sensitivity at 5% blast threshold. Immature granulocyte detection was more sensitive (81% vs 76%, P = 0.086) and specific (88% vs 78%, P = 0.0002) than with CELL-DYN Sapphire. Nucleated red blood cell detection was more sensitive (89% vs 63%, P < 0.001) and just slightly less specific (96% vs 99%, P = 0.0067) than with CELL-DYN Sapphire. Re-run and reflex testing rates were lower with Alinity hq. Conclusion: The Alinity hq hematology analyzer is suitable for clinical use.

AB - Introduction: The analytical and clinical performance as well as the workflow efficiency of the novel, prototype Alinity hq hematology analyzer was evaluated in the clinical laboratory of Universitair Ziekenhuis Brussel, Department of Hematology, Brussels, Belgium. Methods: Within-run and within-laboratory imprecision, linearity, and carryover were assessed using clinical blood samples and commercial blood products. Four hundred and seventeen samples were selected for method comparison with Abbott CELL-DYN Sapphire, and for flagging performance analysis in comparison with smear review and manual microscopic white blood cell (WBC) differential. Results: Within-run and within-laboratory imprecision verification demonstrated low %CV for complete blood count and WBC differential results within the normal ranges (0.1%-10.4%), except for basophil granulocytes. The linearity of the analytical measuring ranges was verified for WBCs, red blood cells, hemoglobin, and platelets. Alinity hq results showed strong agreement with those of CELL-DYN Sapphire. Good correlation was demonstrated with manual WBC differential results, with negative bias for neutrophil (NEU) granulocytes, and positive bias for lymphocytes and monocytes. Blasts were detected with 75% sensitivity and 96% specificity at 1% blast threshold, and 100% sensitivity at 5% blast threshold. Immature granulocyte detection was more sensitive (81% vs 76%, P = 0.086) and specific (88% vs 78%, P = 0.0002) than with CELL-DYN Sapphire. Nucleated red blood cell detection was more sensitive (89% vs 63%, P < 0.001) and just slightly less specific (96% vs 99%, P = 0.0067) than with CELL-DYN Sapphire. Re-run and reflex testing rates were lower with Alinity hq. Conclusion: The Alinity hq hematology analyzer is suitable for clinical use.

KW - Abbott Alinity hq

KW - automated hematology analyzer

KW - complete blood count

KW - performance evaluation

UR - http://www.scopus.com/inward/record.url?scp=85066115091&partnerID=8YFLogxK

U2 - 10.1111/ijlh.13020

DO - 10.1111/ijlh.13020

M3 - Article

VL - 41

SP - 448

EP - 455

JO - International Journal of Laboratory Hematology

JF - International Journal of Laboratory Hematology

SN - 1751-5521

IS - 4

ER -

ID: 46292211