Because Zika virus (ZIKV) can cause serious birth defects and is involved in cases of Guillain-Barré syndrome, the ZIKV outbreak in the American continent in 2015 resulted in an enormous need for ZIKV diagnostic tools. We evaluated the LIAISON® XL Zika Capture IgM test on 106 samples from patients, mainly travelers, with a confirmed or probable ZIKV infection. Sensitivity between 0 and 84 days after onset of symptoms was 92.5%. Specificity was evaluated on a panel of 56 samples known to cause possible cross-reactions. Cross-reaction with DENV antibodies was limited (10.5%) but false-positive results occurred in samples from patients with malaria, CMV and EBV infections.

Original languageEnglish
Pages (from-to)144-148
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume95
Issue number2
DOIs
Publication statusPublished - 2019

    Research areas

  • Antibodies, Viral/blood, Automation, Laboratory, Cross Reactions, Humans, Immunoglobulin M/blood, Retrospective Studies, Sensitivity and Specificity, Serologic Tests/methods, Zika Virus/immunology, Zika Virus Infection/blood

ID: 49211956