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Options for the delivery of anti-pathogen molecules in arthropod vectors. / Caljon, Guy; De Vooght, Linda; Van Den Abbeele, Jan.

In: Journal of Invertebrate Pathology, Vol. 112, No. S1, 03.2013, p. S75-S82.

Research output: Contribution to journalArticle

Harvard

Caljon, G, De Vooght, L & Van Den Abbeele, J 2013, 'Options for the delivery of anti-pathogen molecules in arthropod vectors', Journal of Invertebrate Pathology, vol. 112, no. S1, pp. S75-S82.

APA

Caljon, G., De Vooght, L., & Van Den Abbeele, J. (2013). Options for the delivery of anti-pathogen molecules in arthropod vectors. Journal of Invertebrate Pathology, 112(S1), S75-S82.

Vancouver

Caljon G, De Vooght L, Van Den Abbeele J. Options for the delivery of anti-pathogen molecules in arthropod vectors. Journal of Invertebrate Pathology. 2013 Mar;112(S1):S75-S82.

Author

Caljon, Guy ; De Vooght, Linda ; Van Den Abbeele, Jan. / Options for the delivery of anti-pathogen molecules in arthropod vectors. In: Journal of Invertebrate Pathology. 2013 ; Vol. 112, No. S1. pp. S75-S82.

BibTeX

@article{aedae3d4b4ef4dc1b03fd1edfee96660,
title = "Options for the delivery of anti-pathogen molecules in arthropod vectors",
abstract = "Blood feeding arthropods are responsible for the transmission of a large array of medically important infectious agents that include viruses, bacteria, protozoan parasites and helminths. The recent development of transgenic and paratransgenic technologies have enabled supplementing the immune system of these arthropod vectors with anti-pathogen effector molecules in view of compromising their vector competence for these microbial agents. The characteristics of the selected anti-pathogen compound will largely determine the efficacy and specificity of this approach. Low specificity will generally result in bystander effects, likely having a direct or indirect fitness cost for the arthropod. In contrast, the use of highly specific compounds from the adaptive immune system of vertebrates such as antibody derived fragments is more likely to enable highly specific effects without conferring a selective disadvantage to the (para)transgenic arthropods. Here, Nanobodies{\circledR} are excellent candidates to increase the immune competence of arthropods. Moreover they were shown to exert a novel type of anti-pathogen activity that uniquely depends on their small size.",
keywords = "(para)transgenesis, Vector borne disease, anti-pathogen molecules, nanobody, Tsetse fly, Trypanosomiasis",
author = "Guy Caljon and {De Vooght}, Linda and {Van Den Abbeele}, Jan",
year = "2013",
month = "3",
language = "English",
volume = "112",
pages = "S75--S82",
journal = "Journal of Invertebrate Pathology",
issn = "0022-2011",
publisher = "Academic Press Inc.",
number = "S1",

}

RIS

TY - JOUR

T1 - Options for the delivery of anti-pathogen molecules in arthropod vectors

AU - Caljon, Guy

AU - De Vooght, Linda

AU - Van Den Abbeele, Jan

PY - 2013/3

Y1 - 2013/3

N2 - Blood feeding arthropods are responsible for the transmission of a large array of medically important infectious agents that include viruses, bacteria, protozoan parasites and helminths. The recent development of transgenic and paratransgenic technologies have enabled supplementing the immune system of these arthropod vectors with anti-pathogen effector molecules in view of compromising their vector competence for these microbial agents. The characteristics of the selected anti-pathogen compound will largely determine the efficacy and specificity of this approach. Low specificity will generally result in bystander effects, likely having a direct or indirect fitness cost for the arthropod. In contrast, the use of highly specific compounds from the adaptive immune system of vertebrates such as antibody derived fragments is more likely to enable highly specific effects without conferring a selective disadvantage to the (para)transgenic arthropods. Here, Nanobodies® are excellent candidates to increase the immune competence of arthropods. Moreover they were shown to exert a novel type of anti-pathogen activity that uniquely depends on their small size.

AB - Blood feeding arthropods are responsible for the transmission of a large array of medically important infectious agents that include viruses, bacteria, protozoan parasites and helminths. The recent development of transgenic and paratransgenic technologies have enabled supplementing the immune system of these arthropod vectors with anti-pathogen effector molecules in view of compromising their vector competence for these microbial agents. The characteristics of the selected anti-pathogen compound will largely determine the efficacy and specificity of this approach. Low specificity will generally result in bystander effects, likely having a direct or indirect fitness cost for the arthropod. In contrast, the use of highly specific compounds from the adaptive immune system of vertebrates such as antibody derived fragments is more likely to enable highly specific effects without conferring a selective disadvantage to the (para)transgenic arthropods. Here, Nanobodies® are excellent candidates to increase the immune competence of arthropods. Moreover they were shown to exert a novel type of anti-pathogen activity that uniquely depends on their small size.

KW - (para)transgenesis

KW - Vector borne disease

KW - anti-pathogen molecules

KW - nanobody

KW - Tsetse fly

KW - Trypanosomiasis

M3 - Article

VL - 112

SP - S75-S82

JO - Journal of Invertebrate Pathology

JF - Journal of Invertebrate Pathology

SN - 0022-2011

IS - S1

ER -

ID: 2203185