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Neutrophils enhance early Trypanosoma brucei infection onset. / Caljon, Guy; Mabille, Dorien; Stijlemans, Benoît; De Trez, Carl; Mazzone, Massimiliano; Tacchini-Cottier, Fabienne; Malissen, Marie; A Van Ginderachter, Jo; Magez, Stefan; De Baetselier, Patrick; Van Den Abbeele, Jan.

In: Scientific Reports - Nature, Vol. 8, No. 1, 11203, 25.07.2018.

Research output: Contribution to journalArticleResearchpeer-review

Harvard

Caljon, G, Mabille, D, Stijlemans, B, De Trez, C, Mazzone, M, Tacchini-Cottier, F, Malissen, M, A Van Ginderachter, J, Magez, S, De Baetselier, P & Van Den Abbeele, J 2018, 'Neutrophils enhance early Trypanosoma brucei infection onset' Scientific Reports - Nature, vol. 8, no. 1, 11203. https://doi.org/10.1038/s41598-018-29527-y

APA

Caljon, G., Mabille, D., Stijlemans, B., De Trez, C., Mazzone, M., Tacchini-Cottier, F., ... Van Den Abbeele, J. (2018). Neutrophils enhance early Trypanosoma brucei infection onset. Scientific Reports - Nature, 8(1), [11203]. https://doi.org/10.1038/s41598-018-29527-y

Vancouver

Caljon G, Mabille D, Stijlemans B, De Trez C, Mazzone M, Tacchini-Cottier F et al. Neutrophils enhance early Trypanosoma brucei infection onset. Scientific Reports - Nature. 2018 Jul 25;8(1). 11203. https://doi.org/10.1038/s41598-018-29527-y

Author

Caljon, Guy ; Mabille, Dorien ; Stijlemans, Benoît ; De Trez, Carl ; Mazzone, Massimiliano ; Tacchini-Cottier, Fabienne ; Malissen, Marie ; A Van Ginderachter, Jo ; Magez, Stefan ; De Baetselier, Patrick ; Van Den Abbeele, Jan. / Neutrophils enhance early Trypanosoma brucei infection onset. In: Scientific Reports - Nature. 2018 ; Vol. 8, No. 1.

BibTeX

@article{184553a90141489dbc751e7bd1d3e733,
title = "Neutrophils enhance early Trypanosoma brucei infection onset",
abstract = "In this study, Trypanosoma brucei was naturally transmitted to mice through the bites of infected Glossina morsitans tsetse flies. Neutrophils were recruited rapidly to the bite site, whereas monocytes were attracted more gradually. Expression of inflammatory cytokines (il1b, il6), il10 and neutrophil chemokines (cxcl1, cxcl5) was transiently up-regulated at the site of parasite inoculation. Then, a second influx of neutrophils occurred that coincided with the previously described parasite retention and expansion in the ear dermis. Congenital and experimental neutropenia models, combined with bioluminescent imaging, indicate that neutrophils do not significantly contribute to dermal parasite control and elicit higher systemic parasitemia levels during the infection onset. Engulfment of parasites by neutrophils in the skin was rarely observed and was restricted to parasites with reduced motility/viability, whereas live parasites escaped phagocytosis. To our knowledge, this study represents the first description of a trypanosome infection promoting role of early innate immunological reactions following an infective tsetse fly bite. Our data indicate that the trypanosome is not hindered in its early development and benefits from the host innate responses with the neutrophils being important regulators of the early infection, as already demonstrated for the sand fly transmitted Leishmania parasite.",
author = "Guy Caljon and Dorien Mabille and Beno{\^i}t Stijlemans and {De Trez}, Carl and Massimiliano Mazzone and Fabienne Tacchini-Cottier and Marie Malissen and {A Van Ginderachter}, Jo and Stefan Magez and {De Baetselier}, Patrick and {Van Den Abbeele}, Jan",
year = "2018",
month = "7",
day = "25",
doi = "10.1038/s41598-018-29527-y",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Neutrophils enhance early Trypanosoma brucei infection onset

AU - Caljon, Guy

AU - Mabille, Dorien

AU - Stijlemans, Benoît

AU - De Trez, Carl

AU - Mazzone, Massimiliano

AU - Tacchini-Cottier, Fabienne

AU - Malissen, Marie

AU - A Van Ginderachter, Jo

AU - Magez, Stefan

AU - De Baetselier, Patrick

AU - Van Den Abbeele, Jan

PY - 2018/7/25

Y1 - 2018/7/25

N2 - In this study, Trypanosoma brucei was naturally transmitted to mice through the bites of infected Glossina morsitans tsetse flies. Neutrophils were recruited rapidly to the bite site, whereas monocytes were attracted more gradually. Expression of inflammatory cytokines (il1b, il6), il10 and neutrophil chemokines (cxcl1, cxcl5) was transiently up-regulated at the site of parasite inoculation. Then, a second influx of neutrophils occurred that coincided with the previously described parasite retention and expansion in the ear dermis. Congenital and experimental neutropenia models, combined with bioluminescent imaging, indicate that neutrophils do not significantly contribute to dermal parasite control and elicit higher systemic parasitemia levels during the infection onset. Engulfment of parasites by neutrophils in the skin was rarely observed and was restricted to parasites with reduced motility/viability, whereas live parasites escaped phagocytosis. To our knowledge, this study represents the first description of a trypanosome infection promoting role of early innate immunological reactions following an infective tsetse fly bite. Our data indicate that the trypanosome is not hindered in its early development and benefits from the host innate responses with the neutrophils being important regulators of the early infection, as already demonstrated for the sand fly transmitted Leishmania parasite.

AB - In this study, Trypanosoma brucei was naturally transmitted to mice through the bites of infected Glossina morsitans tsetse flies. Neutrophils were recruited rapidly to the bite site, whereas monocytes were attracted more gradually. Expression of inflammatory cytokines (il1b, il6), il10 and neutrophil chemokines (cxcl1, cxcl5) was transiently up-regulated at the site of parasite inoculation. Then, a second influx of neutrophils occurred that coincided with the previously described parasite retention and expansion in the ear dermis. Congenital and experimental neutropenia models, combined with bioluminescent imaging, indicate that neutrophils do not significantly contribute to dermal parasite control and elicit higher systemic parasitemia levels during the infection onset. Engulfment of parasites by neutrophils in the skin was rarely observed and was restricted to parasites with reduced motility/viability, whereas live parasites escaped phagocytosis. To our knowledge, this study represents the first description of a trypanosome infection promoting role of early innate immunological reactions following an infective tsetse fly bite. Our data indicate that the trypanosome is not hindered in its early development and benefits from the host innate responses with the neutrophils being important regulators of the early infection, as already demonstrated for the sand fly transmitted Leishmania parasite.

UR - http://www.scopus.com/inward/record.url?scp=85050674147&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-29527-y

DO - 10.1038/s41598-018-29527-y

M3 - Article

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 11203

ER -

ID: 41702537