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Neonatal exposure to environmental pollutants and placental mitochondrial DNA content : A multi-pollutant approach. / Vriens, Annette; Nawrot, Tim S; Baeyens, Willy; Den Hond, Elly; Bruckers, Liesbeth; Covaci, Adrian; Croes, Kim; De Craemer, Sam; Govarts, Eva; Lambrechts, Nathalie; Loots, Ilse; Nelen, Vera; Peusens, Martien; De Henauw, Stefaan; Schoeters, Greet; Plusquin, Michelle.

In: Environment International, Vol. 106, 07.06.2017, p. 60-68.

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Harvard

Vriens, A, Nawrot, TS, Baeyens, W, Den Hond, E, Bruckers, L, Covaci, A, Croes, K, De Craemer, S, Govarts, E, Lambrechts, N, Loots, I, Nelen, V, Peusens, M, De Henauw, S, Schoeters, G & Plusquin, M 2017, 'Neonatal exposure to environmental pollutants and placental mitochondrial DNA content: A multi-pollutant approach' Environment International, vol. 106, pp. 60-68. https://doi.org/10.1016/j.envint.2017.05.022

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Author

Vriens, Annette ; Nawrot, Tim S ; Baeyens, Willy ; Den Hond, Elly ; Bruckers, Liesbeth ; Covaci, Adrian ; Croes, Kim ; De Craemer, Sam ; Govarts, Eva ; Lambrechts, Nathalie ; Loots, Ilse ; Nelen, Vera ; Peusens, Martien ; De Henauw, Stefaan ; Schoeters, Greet ; Plusquin, Michelle. / Neonatal exposure to environmental pollutants and placental mitochondrial DNA content : A multi-pollutant approach. In: Environment International. 2017 ; Vol. 106. pp. 60-68.

BibTeX

@article{e209477fd0ea4142ac2f525c053f7829,
title = "Neonatal exposure to environmental pollutants and placental mitochondrial DNA content: A multi-pollutant approach",
abstract = "BACKGROUND: Placental mitochondrial DNA (mtDNA) content can be indicative of oxidative damage to the placenta during fetal development and is responsive to external stressors. In utero exposure to environmental pollutants that may influence placental mtDNA needs further exploration.OBJECTIVES: We evaluated if placental mtDNA content is altered by environmental pollution in newborns and identified pollutants independently associated to alterations in placental mtDNA content.METHODS: mtDNA content was measured in placental tissue of 233 newborns. Four perfluoroalkyl compounds and nine organochlorine compounds were quantified in cord blood plasma samples and six toxic metals in whole cord blood. We first applied a LASSO (least absolute shrinkage and selection operator) penalized regression model to identify independent associations between environmental pollutants and placental mtDNA content, without penalization of several covariates. Then adjusted estimates were obtained using an ordinary least squares (OLS) regression model evaluating the pollutants' association with placental mtDNA content, adjusted for several covariates.RESULTS: Based on LASSO penalized regression, oxychlordane, p,p'-dichlorodiphenyldichloroethylene, β-hexachlorocyclohexane, perfluorononanoic acid, arsenic, cadmium and thallium were identified to be independently associated with placental mtDNA content. The OLS model showed a higher placental mtDNA content of 2.71{\%} (95{\%} CI: 0.3 to 5.2{\%}; p=0.03) and 1.41{\%} (0.1 to 2.8{\%}, p=0.04) for a 25{\%} concentration increase of respectively cord blood β-hexachlorocyclohexane and arsenic. For a 25{\%} concentration increase of cord blood thallium, a 4.88{\%} lower placental mtDNA content (95{\%} CI: -9.1 to -0.5{\%}, p=0.03) was observed.CONCLUSION: In a multi-pollutant approach, low fetal exposure levels of environmental organic and inorganic pollutants might compromise placental mitochondrial function as exemplified in this study by alterations in mtDNA content.",
keywords = "Environmental pollution, Mitochondrial DNA content, Newborns, Placenta, Environmental Monitoring, Metals/blood, Humans, Environmental Pollutants/blood, Male, Fluorocarbons/blood, Hydrocarbons, Chlorinated/blood, Pregnancy, Regression Analysis, Fetal Blood/chemistry, Least-Squares Analysis, Adult, Female, Placenta/chemistry, Arsenic/blood, DNA, Mitochondrial/analysis, Infant, Newborn",
author = "Annette Vriens and Nawrot, {Tim S} and Willy Baeyens and {Den Hond}, Elly and Liesbeth Bruckers and Adrian Covaci and Kim Croes and {De Craemer}, Sam and Eva Govarts and Nathalie Lambrechts and Ilse Loots and Vera Nelen and Martien Peusens and {De Henauw}, Stefaan and Greet Schoeters and Michelle Plusquin",
note = "Copyright {\circledC} 2017 Elsevier Ltd. All rights reserved.",
year = "2017",
month = "6",
day = "7",
doi = "10.1016/j.envint.2017.05.022",
language = "English",
volume = "106",
pages = "60--68",
journal = "Environment International",
issn = "0160-4120",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Neonatal exposure to environmental pollutants and placental mitochondrial DNA content

T2 - A multi-pollutant approach

AU - Vriens, Annette

AU - Nawrot, Tim S

AU - Baeyens, Willy

AU - Den Hond, Elly

AU - Bruckers, Liesbeth

AU - Covaci, Adrian

AU - Croes, Kim

AU - De Craemer, Sam

AU - Govarts, Eva

AU - Lambrechts, Nathalie

AU - Loots, Ilse

AU - Nelen, Vera

AU - Peusens, Martien

AU - De Henauw, Stefaan

AU - Schoeters, Greet

AU - Plusquin, Michelle

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017/6/7

Y1 - 2017/6/7

N2 - BACKGROUND: Placental mitochondrial DNA (mtDNA) content can be indicative of oxidative damage to the placenta during fetal development and is responsive to external stressors. In utero exposure to environmental pollutants that may influence placental mtDNA needs further exploration.OBJECTIVES: We evaluated if placental mtDNA content is altered by environmental pollution in newborns and identified pollutants independently associated to alterations in placental mtDNA content.METHODS: mtDNA content was measured in placental tissue of 233 newborns. Four perfluoroalkyl compounds and nine organochlorine compounds were quantified in cord blood plasma samples and six toxic metals in whole cord blood. We first applied a LASSO (least absolute shrinkage and selection operator) penalized regression model to identify independent associations between environmental pollutants and placental mtDNA content, without penalization of several covariates. Then adjusted estimates were obtained using an ordinary least squares (OLS) regression model evaluating the pollutants' association with placental mtDNA content, adjusted for several covariates.RESULTS: Based on LASSO penalized regression, oxychlordane, p,p'-dichlorodiphenyldichloroethylene, β-hexachlorocyclohexane, perfluorononanoic acid, arsenic, cadmium and thallium were identified to be independently associated with placental mtDNA content. The OLS model showed a higher placental mtDNA content of 2.71% (95% CI: 0.3 to 5.2%; p=0.03) and 1.41% (0.1 to 2.8%, p=0.04) for a 25% concentration increase of respectively cord blood β-hexachlorocyclohexane and arsenic. For a 25% concentration increase of cord blood thallium, a 4.88% lower placental mtDNA content (95% CI: -9.1 to -0.5%, p=0.03) was observed.CONCLUSION: In a multi-pollutant approach, low fetal exposure levels of environmental organic and inorganic pollutants might compromise placental mitochondrial function as exemplified in this study by alterations in mtDNA content.

AB - BACKGROUND: Placental mitochondrial DNA (mtDNA) content can be indicative of oxidative damage to the placenta during fetal development and is responsive to external stressors. In utero exposure to environmental pollutants that may influence placental mtDNA needs further exploration.OBJECTIVES: We evaluated if placental mtDNA content is altered by environmental pollution in newborns and identified pollutants independently associated to alterations in placental mtDNA content.METHODS: mtDNA content was measured in placental tissue of 233 newborns. Four perfluoroalkyl compounds and nine organochlorine compounds were quantified in cord blood plasma samples and six toxic metals in whole cord blood. We first applied a LASSO (least absolute shrinkage and selection operator) penalized regression model to identify independent associations between environmental pollutants and placental mtDNA content, without penalization of several covariates. Then adjusted estimates were obtained using an ordinary least squares (OLS) regression model evaluating the pollutants' association with placental mtDNA content, adjusted for several covariates.RESULTS: Based on LASSO penalized regression, oxychlordane, p,p'-dichlorodiphenyldichloroethylene, β-hexachlorocyclohexane, perfluorononanoic acid, arsenic, cadmium and thallium were identified to be independently associated with placental mtDNA content. The OLS model showed a higher placental mtDNA content of 2.71% (95% CI: 0.3 to 5.2%; p=0.03) and 1.41% (0.1 to 2.8%, p=0.04) for a 25% concentration increase of respectively cord blood β-hexachlorocyclohexane and arsenic. For a 25% concentration increase of cord blood thallium, a 4.88% lower placental mtDNA content (95% CI: -9.1 to -0.5%, p=0.03) was observed.CONCLUSION: In a multi-pollutant approach, low fetal exposure levels of environmental organic and inorganic pollutants might compromise placental mitochondrial function as exemplified in this study by alterations in mtDNA content.

KW - Environmental pollution

KW - Mitochondrial DNA content

KW - Newborns

KW - Placenta

KW - Environmental Monitoring

KW - Metals/blood

KW - Humans

KW - Environmental Pollutants/blood

KW - Male

KW - Fluorocarbons/blood

KW - Hydrocarbons, Chlorinated/blood

KW - Pregnancy

KW - Regression Analysis

KW - Fetal Blood/chemistry

KW - Least-Squares Analysis

KW - Adult

KW - Female

KW - Placenta/chemistry

KW - Arsenic/blood

KW - DNA, Mitochondrial/analysis

KW - Infant, Newborn

UR - http://www.scopus.com/inward/record.url?scp=85020311923&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2017.05.022

DO - 10.1016/j.envint.2017.05.022

M3 - Article

VL - 106

SP - 60

EP - 68

JO - Environment International

JF - Environment International

SN - 0160-4120

ER -

ID: 32425096