• Judith E Grolleman
  • Richarda M de Voer
  • Fadwa A Elsayed
  • Maartje Nielsen
  • Robbert D A Weren
  • Claire Palles
  • Marjolijn J L Ligtenberg
  • Janet R Vos
  • Sanne W Ten Broeke
  • Noel F C C de Miranda
  • Renske A Kuiper
  • Eveline J Kamping
  • Erik A M Jansen
  • M Elisa Vink-Börger
  • Isabell Popp
  • Alois Lang
  • Isabel Spier
  • Robert Hüneburg
  • Paul A James
  • Na Li
  • Marija Staninova
  • Helen Lindsay
  • David Cockburn
  • Olivera Spasic-Boskovic
  • Mark Clendenning
  • Kevin Sweet
  • Gabriel Capellá
  • Wenche Sjursen
  • Hildegunn Høberg-Vetti
  • Marjolijn C Jongmans
  • Kornelia Neveling
  • Ad Geurts van Kessel
  • Hans Morreau
  • Rolf H Sijmons
  • Hans K Schackert
  • Clara Ruiz-Ponte
  • Dagmara Dymerska
  • Jan Lubinski
  • Barbara Rivera
  • William D Foulkes
  • Ian P Tomlinson
  • Laura Valle
  • Daniel D Buchanan
  • Sue Kenwrick
  • Julian Adlard
  • Aleksandar J Dimovski
  • Ian G Campbell
  • Stefan Aretz
  • Detlev Schindler
  • Tom van Wezel
  • Nicoline Hoogerbrugge
  • Roland P Kuiper

Biallelic germline mutations affecting NTHL1 predispose carriers to adenomatous polyposis and colorectal cancer, but the complete phenotype is unknown. We describe 29 individuals carrying biallelic germline NTHL1 mutations from 17 families, of which 26 developed one (n = 10) or multiple (n = 16) malignancies in 14 different tissues. An unexpected high breast cancer incidence was observed in female carriers (60%). Mutational signature analysis of 14 tumors from 7 organs revealed that NTHL1 deficiency underlies the main mutational process in all but one of the tumors (93%). These results reveal NTHL1 as a multi-tumor predisposition gene with a high lifetime risk for extracolonic cancers and a typical mutational signature observed across tumor types, which can assist in the recognition of this syndrome.

Original languageEnglish
Pages (from-to)256-266.e5
Number of pages11
JournalCancer Cell
Issue number2
Publication statusPublished - 11 Feb 2019

    Research areas

  • DNA repair defect, NTHL1, adenomatous polyposis, base excision repair, breast cancer, colorectal cancer, genetic predisposition, multiple malignancies, mutational signature, somatic mutation spectrum

ID: 44276109