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Industrial, biocide and cosmetic chemical inducers of cholestasis. / Vilas-Boas, Vânia; Gijbels, Eva; Cooreman, Axelle; Van Campenhout, Raf; Gustafson, Emma; Leroy, Kaat; Vinken, Mathieu.

In: Chemical Research in Toxicology, Vol. 32, No. 7, 03.06.2019, p. 1327-1334.

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@article{cc3147571c514c73b77ee99f93bb7012,
title = "Industrial, biocide and cosmetic chemical inducers of cholestasis",
abstract = "A frequent side effect of many drugs includes the occurrence of cholestatic liver toxicity. Over the past couple of decades, drug-induced cholestasis has gained considerable attention, resulting in a plethora of data regarding its prevalence and mechanistic basis. Likewise, several food additives and dietary supplements have been reported to cause cholestatic liver insults in the past few years. The induction of cholestatic hepatotoxicity by other types of chemicals, in particular synthetic compounds, such as industrial chemicals, biocides, and cosmetic ingredients, has been much less documented. Such information can be found in occasional clinical case reports of accidental intake or suicide attempts as well as in basic and translational study reports on mechanisms or testing of new therapeutics in cholestatic animal models. This paper focuses on such nonpharmaceutical and nondietary synthetic chemical inducers of cholestatic liver injury, in particular alpha-naphthylisocyanate, 3,5-diethoxycarbonyl-1,4-dihydrocollidine, methylenedianiline, paraquat, tartrazine, triclosan, 2-octynoic acid, and 2-nonynoic acid. Most of these cholestatic compounds act by similar mechanisms. This could open perspectives for the prediction of cholestatic potential of chemicals.",
author = "V{\^a}nia Vilas-Boas and Eva Gijbels and Axelle Cooreman and {Van Campenhout}, Raf and Emma Gustafson and Kaat Leroy and Mathieu Vinken",
year = "2019",
month = "6",
day = "3",
doi = "10.1021/acs.chemrestox.9b00148",
language = "English",
volume = "32",
pages = "1327--1334",
journal = "Chemical Research in Toxicology",
issn = "0893-228X",
publisher = "American Chemical Society",
number = "7",

}

RIS

TY - JOUR

T1 - Industrial, biocide and cosmetic chemical inducers of cholestasis

AU - Vilas-Boas, Vânia

AU - Gijbels, Eva

AU - Cooreman, Axelle

AU - Van Campenhout, Raf

AU - Gustafson, Emma

AU - Leroy, Kaat

AU - Vinken, Mathieu

PY - 2019/6/3

Y1 - 2019/6/3

N2 - A frequent side effect of many drugs includes the occurrence of cholestatic liver toxicity. Over the past couple of decades, drug-induced cholestasis has gained considerable attention, resulting in a plethora of data regarding its prevalence and mechanistic basis. Likewise, several food additives and dietary supplements have been reported to cause cholestatic liver insults in the past few years. The induction of cholestatic hepatotoxicity by other types of chemicals, in particular synthetic compounds, such as industrial chemicals, biocides, and cosmetic ingredients, has been much less documented. Such information can be found in occasional clinical case reports of accidental intake or suicide attempts as well as in basic and translational study reports on mechanisms or testing of new therapeutics in cholestatic animal models. This paper focuses on such nonpharmaceutical and nondietary synthetic chemical inducers of cholestatic liver injury, in particular alpha-naphthylisocyanate, 3,5-diethoxycarbonyl-1,4-dihydrocollidine, methylenedianiline, paraquat, tartrazine, triclosan, 2-octynoic acid, and 2-nonynoic acid. Most of these cholestatic compounds act by similar mechanisms. This could open perspectives for the prediction of cholestatic potential of chemicals.

AB - A frequent side effect of many drugs includes the occurrence of cholestatic liver toxicity. Over the past couple of decades, drug-induced cholestasis has gained considerable attention, resulting in a plethora of data regarding its prevalence and mechanistic basis. Likewise, several food additives and dietary supplements have been reported to cause cholestatic liver insults in the past few years. The induction of cholestatic hepatotoxicity by other types of chemicals, in particular synthetic compounds, such as industrial chemicals, biocides, and cosmetic ingredients, has been much less documented. Such information can be found in occasional clinical case reports of accidental intake or suicide attempts as well as in basic and translational study reports on mechanisms or testing of new therapeutics in cholestatic animal models. This paper focuses on such nonpharmaceutical and nondietary synthetic chemical inducers of cholestatic liver injury, in particular alpha-naphthylisocyanate, 3,5-diethoxycarbonyl-1,4-dihydrocollidine, methylenedianiline, paraquat, tartrazine, triclosan, 2-octynoic acid, and 2-nonynoic acid. Most of these cholestatic compounds act by similar mechanisms. This could open perspectives for the prediction of cholestatic potential of chemicals.

UR - http://www.scopus.com/inward/record.url?scp=85069888715&partnerID=8YFLogxK

U2 - 10.1021/acs.chemrestox.9b00148

DO - 10.1021/acs.chemrestox.9b00148

M3 - Article

VL - 32

SP - 1327

EP - 1334

JO - Chemical Research in Toxicology

JF - Chemical Research in Toxicology

SN - 0893-228X

IS - 7

ER -

ID: 45854980