Multiple myeloma (MM) is a malignant B cell disorder characterized by the accumulation of neoplastic plasma cells in the bone marrow (BM). One of the major characteristics of MM is the occurrence of bone lesions, caused by an imbalance between osteoblastic and osteoclastic function. Mesenchymal stem cells (MSCs) are a population of multipotent stem cells, which have the potential to differentiate into different mesenchymal tissues. Several previous studies indicated that BM-derived MSCs from MM patients showed an enhanced production of cytokines and a distinctive gene expression profile, as compared to their normal counterparts. Although osteoblastic function is decreased in advanced MM, regarding whether and at which level the differentiation of MSCs towards osteoblasts is impaired in this disease, the reports are not unanimous.
Original languageEnglish
Pages (from-to)2546-2549
JournalLeukemia
Volume26
Issue number12
Publication statusPublished - 8 Jun 2012

    Research areas

  • myeloma

ID: 2170162