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@article{c517fd1a34ba49f7808538317a0e2b5d,
title = "Impact of endometrial polyps detected during the follicular phase of intrauterine insemination treatments",
abstract = "Research question: Endometrial polyps are a frequent finding during fertility treatment. Although up to 27{\%} of small polyps (<10 mm) regress spontaneously, there is clinical benefit to removing a polyp detected before intrauterine insemination (IUI), regardless of size. However, the clinical outcome of IUI following a new suspicion of a polyp during follicle tracking is unknown. Design: This retrospective cohort study included all patients with a normal baseline uterine ultrasound and/or hysteroscopy result who started an IUI cycle between May 2009 and March 2017. In 139 of 6606 patients (2.1{\%}), encompassing 340 out of 15,147 cycles (2.3{\%} of cycles), a polyp was diagnosed during the follicular phase. The 6467 controls had ultrasound results with no suspicion of a polyp. Each patient was included only once in the analysis during a maximum of three consecutive cycles of IUI. Results: Female age was significantly higher in the polyp group than the controls (35.4 ± 4.8 versus 33.0 ± 5.0, P < 0.01). The unadjusted cumulative live birth rate (CLBR) after three IUI cycles in women with and without a polyp was 24.1{\%} versus 33.0{\%} (P = 0.03), indicating a deleterious effect of polyp(s). However, after multivariate Cox regression analysis for body mass index, female age, number of follicles and sperm concentration, the presence of a polyp appeared not to influence the CLBR (adjusted hazard ratio 0.742, 95{\%} confidence interval 0.477–1.156, P = 0.19). Conclusions: These results may be reassuring, as ultrasound diagnosis of a polyp during the follicular phase of an IUI cycle does not seem to compromise clinical outcome when previous baseline examinations have been normal.",
keywords = "endometrial polyps, follicular phase, intrauterine insemination treatments, fertility",
author = "Valerie Schutyser and {Dos Santos Ribeiro}, Samuel and Michel Camus and Liese Boudry and {De Vos}, Michel and Herman Tournaye and Christophe Blockeel",
year = "2020",
month = "3",
day = "13",
doi = "10.1016/j.rbmo.2020.03.004",
language = "English",
volume = "41",
pages = "62--68",
journal = "Reproductive BioMedicine Online",
issn = "1472-6483",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Impact of endometrial polyps detected during the follicular phase of intrauterine insemination treatments

AU - Schutyser, Valerie

AU - Dos Santos Ribeiro, Samuel

AU - Camus, Michel

AU - Boudry, Liese

AU - De Vos, Michel

AU - Tournaye, Herman

AU - Blockeel, Christophe

PY - 2020/3/13

Y1 - 2020/3/13

N2 - Research question: Endometrial polyps are a frequent finding during fertility treatment. Although up to 27% of small polyps (<10 mm) regress spontaneously, there is clinical benefit to removing a polyp detected before intrauterine insemination (IUI), regardless of size. However, the clinical outcome of IUI following a new suspicion of a polyp during follicle tracking is unknown. Design: This retrospective cohort study included all patients with a normal baseline uterine ultrasound and/or hysteroscopy result who started an IUI cycle between May 2009 and March 2017. In 139 of 6606 patients (2.1%), encompassing 340 out of 15,147 cycles (2.3% of cycles), a polyp was diagnosed during the follicular phase. The 6467 controls had ultrasound results with no suspicion of a polyp. Each patient was included only once in the analysis during a maximum of three consecutive cycles of IUI. Results: Female age was significantly higher in the polyp group than the controls (35.4 ± 4.8 versus 33.0 ± 5.0, P < 0.01). The unadjusted cumulative live birth rate (CLBR) after three IUI cycles in women with and without a polyp was 24.1% versus 33.0% (P = 0.03), indicating a deleterious effect of polyp(s). However, after multivariate Cox regression analysis for body mass index, female age, number of follicles and sperm concentration, the presence of a polyp appeared not to influence the CLBR (adjusted hazard ratio 0.742, 95% confidence interval 0.477–1.156, P = 0.19). Conclusions: These results may be reassuring, as ultrasound diagnosis of a polyp during the follicular phase of an IUI cycle does not seem to compromise clinical outcome when previous baseline examinations have been normal.

AB - Research question: Endometrial polyps are a frequent finding during fertility treatment. Although up to 27% of small polyps (<10 mm) regress spontaneously, there is clinical benefit to removing a polyp detected before intrauterine insemination (IUI), regardless of size. However, the clinical outcome of IUI following a new suspicion of a polyp during follicle tracking is unknown. Design: This retrospective cohort study included all patients with a normal baseline uterine ultrasound and/or hysteroscopy result who started an IUI cycle between May 2009 and March 2017. In 139 of 6606 patients (2.1%), encompassing 340 out of 15,147 cycles (2.3% of cycles), a polyp was diagnosed during the follicular phase. The 6467 controls had ultrasound results with no suspicion of a polyp. Each patient was included only once in the analysis during a maximum of three consecutive cycles of IUI. Results: Female age was significantly higher in the polyp group than the controls (35.4 ± 4.8 versus 33.0 ± 5.0, P < 0.01). The unadjusted cumulative live birth rate (CLBR) after three IUI cycles in women with and without a polyp was 24.1% versus 33.0% (P = 0.03), indicating a deleterious effect of polyp(s). However, after multivariate Cox regression analysis for body mass index, female age, number of follicles and sperm concentration, the presence of a polyp appeared not to influence the CLBR (adjusted hazard ratio 0.742, 95% confidence interval 0.477–1.156, P = 0.19). Conclusions: These results may be reassuring, as ultrasound diagnosis of a polyp during the follicular phase of an IUI cycle does not seem to compromise clinical outcome when previous baseline examinations have been normal.

KW - endometrial polyps

KW - follicular phase

KW - intrauterine insemination treatments

KW - fertility

UR - http://dx.doi.org/10.1016/j.rbmo.2020.03.004

UR - http://www.scopus.com/inward/record.url?scp=85085015578&partnerID=8YFLogxK

U2 - 10.1016/j.rbmo.2020.03.004

DO - 10.1016/j.rbmo.2020.03.004

M3 - Article

VL - 41

SP - 62

EP - 68

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

SN - 1472-6483

IS - 1

ER -

ID: 51766485