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Immune Players in the CNS: The Astrocyte. / Jensen, Cathy; Massie, Ann; De Keyser, Jacques.

In: Journal of Neuroimmune Pharmacology, Vol. 8, 09.2013, p. 824-839.

Research output: Contribution to journalArticle

Harvard

Jensen, C, Massie, A & De Keyser, J 2013, 'Immune Players in the CNS: The Astrocyte', Journal of Neuroimmune Pharmacology, vol. 8, pp. 824-839.

APA

Jensen, C., Massie, A., & De Keyser, J. (2013). Immune Players in the CNS: The Astrocyte. Journal of Neuroimmune Pharmacology, 8, 824-839.

Vancouver

Jensen C, Massie A, De Keyser J. Immune Players in the CNS: The Astrocyte. Journal of Neuroimmune Pharmacology. 2013 Sep;8:824-839.

Author

Jensen, Cathy ; Massie, Ann ; De Keyser, Jacques. / Immune Players in the CNS: The Astrocyte. In: Journal of Neuroimmune Pharmacology. 2013 ; Vol. 8. pp. 824-839.

BibTeX

@article{d648f188cd26448bbaa9b5158e730b62,
title = "Immune Players in the CNS: The Astrocyte",
abstract = "The finely balanced environment of the central nervous system astrocytes, the most numerous cell type, play a role in regulating almost every physiological system. First found to regulate extracellular ions and pH, they have since been shown to regulate neurotransmitter levels, cerebral blood flow and energy metabolism. There is also growing evidence for an essential role of astrocytes in central immunity, which is the topic of this review. In the healthy state, the central nervous system is potently anti-inflammatory but under threat astrocytes readily respond to pathogens and to both sterile and pathogen-induced cell damage. In response, astrocytes take on some of the roles of immune cells, releasing cyto- and chemokines to influence effector cells, modulating the blood-brain barrier and forming glial scars. To date, much of the data supporting a role for astrocytes in immunity have been obtained from in vitro systems; however data from experimental models and clinical samples support the suggestion that astrocytes perform similar roles in more complex environments. This review will discuss some aspects of the role of astrocytes in central nervous system immunity.",
keywords = "astrocyte, immunity, cytokine, chemokine, APC, PAMP, astrogliosis",
author = "Cathy Jensen and Ann Massie and {De Keyser}, Jacques",
year = "2013",
month = "9",
language = "English",
volume = "8",
pages = "824--839",
journal = "Journal of Neuroimmune Pharmacology",
issn = "1557-1890",
publisher = "Springer New York",

}

RIS

TY - JOUR

T1 - Immune Players in the CNS: The Astrocyte

AU - Jensen, Cathy

AU - Massie, Ann

AU - De Keyser, Jacques

PY - 2013/9

Y1 - 2013/9

N2 - The finely balanced environment of the central nervous system astrocytes, the most numerous cell type, play a role in regulating almost every physiological system. First found to regulate extracellular ions and pH, they have since been shown to regulate neurotransmitter levels, cerebral blood flow and energy metabolism. There is also growing evidence for an essential role of astrocytes in central immunity, which is the topic of this review. In the healthy state, the central nervous system is potently anti-inflammatory but under threat astrocytes readily respond to pathogens and to both sterile and pathogen-induced cell damage. In response, astrocytes take on some of the roles of immune cells, releasing cyto- and chemokines to influence effector cells, modulating the blood-brain barrier and forming glial scars. To date, much of the data supporting a role for astrocytes in immunity have been obtained from in vitro systems; however data from experimental models and clinical samples support the suggestion that astrocytes perform similar roles in more complex environments. This review will discuss some aspects of the role of astrocytes in central nervous system immunity.

AB - The finely balanced environment of the central nervous system astrocytes, the most numerous cell type, play a role in regulating almost every physiological system. First found to regulate extracellular ions and pH, they have since been shown to regulate neurotransmitter levels, cerebral blood flow and energy metabolism. There is also growing evidence for an essential role of astrocytes in central immunity, which is the topic of this review. In the healthy state, the central nervous system is potently anti-inflammatory but under threat astrocytes readily respond to pathogens and to both sterile and pathogen-induced cell damage. In response, astrocytes take on some of the roles of immune cells, releasing cyto- and chemokines to influence effector cells, modulating the blood-brain barrier and forming glial scars. To date, much of the data supporting a role for astrocytes in immunity have been obtained from in vitro systems; however data from experimental models and clinical samples support the suggestion that astrocytes perform similar roles in more complex environments. This review will discuss some aspects of the role of astrocytes in central nervous system immunity.

KW - astrocyte

KW - immunity

KW - cytokine

KW - chemokine

KW - APC

KW - PAMP

KW - astrogliosis

M3 - Article

VL - 8

SP - 824

EP - 839

JO - Journal of Neuroimmune Pharmacology

JF - Journal of Neuroimmune Pharmacology

SN - 1557-1890

ER -

ID: 2377518