Epilepsy is a neurological disorder that affects more than 50 million people worldwide. One-third of all epilepsy patients do not respond to the antiepileptic medications that are currently available. As such, there is a great need for new, more effective drugs for the treatment of epilepsy. Drugs that target neuropeptide systems in the brain show great promise for preventing seizures and epilepsy. Little is currently known about the ghrelin receptor and its role in epilepsy. In this chapter, we discuss whether the ghrelin system is a promising target to stop seizures or prevent the development of epilepsy. This is done by looking at what is currently known, as well as what physiological functions of the ghrelin receptor may be beneficial in epilepsy. The final part of this chapter highlights a number of factors that need to be investigated to understand better the function of the ghrelin receptor in epileptic states. These suggestions may indirectly give an insight to researchers studying ghrelin in other fields of research.
Original languageEnglish
Title of host publicationThe Receptors : Central Functions of the Ghrelin Receptor
Place of PublicationNew York
PublisherSpringer
Pages177-189
Number of pages13
Volume25
ISBN (Print)978-1-4939-0822-6
Publication statusPublished - 2014

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