BACKGROUND: Gastro-oesophageal reflux (GOR) is common in patients with cystic fibrosis (CF). The aim of this study was to investigate the relationship between gastric emptying (GE) and GOR in children with CF.

METHODS: Multichannel intraluminal impedance-pH monitoring (MII-pH) to measure GOR and GE breath test (GEBT) to measure GE were performed in 28 children with symptoms suggestive for GOR disease (GORD) (group 1). GEBT was performed in another 28 children with/without GOR symptoms who agreed to undergo GEBT but not MII-pH (group 2).

RESULTS: In group 1, we found increased acid GOR (AGOR) in 46.4% and delayed GE (DGE) in 21.4% but no relationship between increased AGOR and DGE. There was no DGE in group 2. We found DGE in 10.7% and rapid GE in 12.5% of the whole group.

CONCLUSIONS: Almost half of the children with CF and symptoms suggestive for GORD have increased AGOR and almost a quarter has DGE. However, there was no relation between GOR and GE.

Original languageEnglish
Pages (from-to)540-547
Number of pages8
JournalJournal of Cystic Fibrosis
Issue number4
Early online date8 Jan 2016
Publication statusPublished - Jul 2016

    Research areas

  • 13)C-gastric emptying breath test, Children, Cystic fibrosis, Gastric emptying, Gastro-oesophageal reflux, Multichannel intraluminal impedance-pH monitoring

ID: 22044477