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Disproportion and dysmorphism in an adult Belgian population with Turner syndrome : risk factors for chronic diseases? / Van De Kelft, An-Sofie; Lievens, Charlotte; De Groote, Katya; Demulier, Laurent; De Backer, Julie; T'Sjoen, Guy; Craen, Margarita; Callewaert, Bert; De Schepper, Jean.

In: Acta Clinica Belgica, Vol. 75, No. 4, 08.2020, p. 258-266.

Research output: Contribution to journalArticle

Harvard

Van De Kelft, A-S, Lievens, C, De Groote, K, Demulier, L, De Backer, J, T'Sjoen, G, Craen, M, Callewaert, B & De Schepper, J 2020, 'Disproportion and dysmorphism in an adult Belgian population with Turner syndrome: risk factors for chronic diseases?', Acta Clinica Belgica, vol. 75, no. 4, pp. 258-266. https://doi.org/10.1080/17843286.2019.1606761

APA

Van De Kelft, A-S., Lievens, C., De Groote, K., Demulier, L., De Backer, J., T'Sjoen, G., ... De Schepper, J. (2020). Disproportion and dysmorphism in an adult Belgian population with Turner syndrome: risk factors for chronic diseases? Acta Clinica Belgica, 75(4), 258-266. https://doi.org/10.1080/17843286.2019.1606761

Vancouver

Van De Kelft A-S, Lievens C, De Groote K, Demulier L, De Backer J, T'Sjoen G et al. Disproportion and dysmorphism in an adult Belgian population with Turner syndrome: risk factors for chronic diseases? Acta Clinica Belgica. 2020 Aug;75(4):258-266. https://doi.org/10.1080/17843286.2019.1606761

Author

Van De Kelft, An-Sofie ; Lievens, Charlotte ; De Groote, Katya ; Demulier, Laurent ; De Backer, Julie ; T'Sjoen, Guy ; Craen, Margarita ; Callewaert, Bert ; De Schepper, Jean. / Disproportion and dysmorphism in an adult Belgian population with Turner syndrome : risk factors for chronic diseases?. In: Acta Clinica Belgica. 2020 ; Vol. 75, No. 4. pp. 258-266.

BibTeX

@article{00b602761db6490e900550bc8c866122,
title = "Disproportion and dysmorphism in an adult Belgian population with Turner syndrome: risk factors for chronic diseases?",
abstract = "BACKGROUND: Turner syndrome (TS) is characterized by dysmorphism and body disproportion. TS women are also susceptible to a range of chronic disorders including arterial hypertension (AHT), osteoporosis, sensorineural hearing loss (SNHL), type 2 diabetes mellitus (DM2) and thyroid disease. The association between dysmorphism/body disproportion and chronic disease has never been studied in TS women. The effect of growth hormone treatment on body disproportion is also unclear. Objectives: to analyze dysmorphic features and body disproportion in TS women in relation to the presence of chronic disease and to document the effect of growth hormone therapy on body disproportion.METHOD: 76 adult TS women with a regular follow up at the TS clinic UZ Ghent were invited to participate. Detailed body measurements were performed in 44 volunteering TS women. Scoring systems for overall dysmorphism, craniofacial dysmorphism, thoracic and limb abnormalities and skeletal disproportion were developed.RESULTS: TS women with a higher dysmorphism score were more at risk for AHT (p = 0.04) as well as those with a higher sitting height/standing height ratio (p < 0.05). Prevalence of AHT, osteoporosis and DM 2 was lower in TS women treated with GH during childhood (p < 0.05).CONCLUSIONS: Adult TS women with relatively short legs or with more physical dysmorphic stigmata were more at risk for AHT. GH therapy does not seem to increase the risk of chronic disease on the long term.",
keywords = "Body disproportion, GH, Ullrich-Turner syndrome, chronic diseases, dysmorphism",
author = "{Van De Kelft}, An-Sofie and Charlotte Lievens and {De Groote}, Katya and Laurent Demulier and {De Backer}, Julie and Guy T'Sjoen and Margarita Craen and Bert Callewaert and {De Schepper}, Jean",
year = "2020",
month = "8",
doi = "10.1080/17843286.2019.1606761",
language = "English",
volume = "75",
pages = "258--266",
journal = "Acta Clinica Belgica",
issn = "0001-5512",
publisher = "Acta Clinica Belgica",
number = "4",

}

RIS

TY - JOUR

T1 - Disproportion and dysmorphism in an adult Belgian population with Turner syndrome

T2 - risk factors for chronic diseases?

AU - Van De Kelft, An-Sofie

AU - Lievens, Charlotte

AU - De Groote, Katya

AU - Demulier, Laurent

AU - De Backer, Julie

AU - T'Sjoen, Guy

AU - Craen, Margarita

AU - Callewaert, Bert

AU - De Schepper, Jean

PY - 2020/8

Y1 - 2020/8

N2 - BACKGROUND: Turner syndrome (TS) is characterized by dysmorphism and body disproportion. TS women are also susceptible to a range of chronic disorders including arterial hypertension (AHT), osteoporosis, sensorineural hearing loss (SNHL), type 2 diabetes mellitus (DM2) and thyroid disease. The association between dysmorphism/body disproportion and chronic disease has never been studied in TS women. The effect of growth hormone treatment on body disproportion is also unclear. Objectives: to analyze dysmorphic features and body disproportion in TS women in relation to the presence of chronic disease and to document the effect of growth hormone therapy on body disproportion.METHOD: 76 adult TS women with a regular follow up at the TS clinic UZ Ghent were invited to participate. Detailed body measurements were performed in 44 volunteering TS women. Scoring systems for overall dysmorphism, craniofacial dysmorphism, thoracic and limb abnormalities and skeletal disproportion were developed.RESULTS: TS women with a higher dysmorphism score were more at risk for AHT (p = 0.04) as well as those with a higher sitting height/standing height ratio (p < 0.05). Prevalence of AHT, osteoporosis and DM 2 was lower in TS women treated with GH during childhood (p < 0.05).CONCLUSIONS: Adult TS women with relatively short legs or with more physical dysmorphic stigmata were more at risk for AHT. GH therapy does not seem to increase the risk of chronic disease on the long term.

AB - BACKGROUND: Turner syndrome (TS) is characterized by dysmorphism and body disproportion. TS women are also susceptible to a range of chronic disorders including arterial hypertension (AHT), osteoporosis, sensorineural hearing loss (SNHL), type 2 diabetes mellitus (DM2) and thyroid disease. The association between dysmorphism/body disproportion and chronic disease has never been studied in TS women. The effect of growth hormone treatment on body disproportion is also unclear. Objectives: to analyze dysmorphic features and body disproportion in TS women in relation to the presence of chronic disease and to document the effect of growth hormone therapy on body disproportion.METHOD: 76 adult TS women with a regular follow up at the TS clinic UZ Ghent were invited to participate. Detailed body measurements were performed in 44 volunteering TS women. Scoring systems for overall dysmorphism, craniofacial dysmorphism, thoracic and limb abnormalities and skeletal disproportion were developed.RESULTS: TS women with a higher dysmorphism score were more at risk for AHT (p = 0.04) as well as those with a higher sitting height/standing height ratio (p < 0.05). Prevalence of AHT, osteoporosis and DM 2 was lower in TS women treated with GH during childhood (p < 0.05).CONCLUSIONS: Adult TS women with relatively short legs or with more physical dysmorphic stigmata were more at risk for AHT. GH therapy does not seem to increase the risk of chronic disease on the long term.

KW - Body disproportion

KW - GH

KW - Ullrich-Turner syndrome

KW - chronic diseases

KW - dysmorphism

U2 - 10.1080/17843286.2019.1606761

DO - 10.1080/17843286.2019.1606761

M3 - Article

C2 - 31025600

VL - 75

SP - 258

EP - 266

JO - Acta Clinica Belgica

JF - Acta Clinica Belgica

SN - 0001-5512

IS - 4

ER -

ID: 53412941