Standard

Determination of free thyroid hormones. / Thienpont, Lm; Van Uytfanghe, K.; Poppe, Kris; Velkeniers-Hoebanckx, Brigitte.

In: Best Practice & Research Clinical Endocrinology & Metabolism, Vol. 27, No. 5, 2013, p. 689-700.

Research output: Contribution to journalArticle

Harvard

Thienpont, L, Van Uytfanghe, K, Poppe, K & Velkeniers-Hoebanckx, B 2013, 'Determination of free thyroid hormones', Best Practice & Research Clinical Endocrinology & Metabolism, vol. 27, no. 5, pp. 689-700.

APA

Thienpont, L., Van Uytfanghe, K., Poppe, K., & Velkeniers-Hoebanckx, B. (2013). Determination of free thyroid hormones. Best Practice & Research Clinical Endocrinology & Metabolism, 27(5), 689-700.

Vancouver

Thienpont L, Van Uytfanghe K, Poppe K, Velkeniers-Hoebanckx B. Determination of free thyroid hormones. Best Practice & Research Clinical Endocrinology & Metabolism. 2013;27(5):689-700.

Author

Thienpont, Lm ; Van Uytfanghe, K. ; Poppe, Kris ; Velkeniers-Hoebanckx, Brigitte. / Determination of free thyroid hormones. In: Best Practice & Research Clinical Endocrinology & Metabolism. 2013 ; Vol. 27, No. 5. pp. 689-700.

BibTeX

@article{9eb9b344b6864e2f8699bf7eb38ce54d,
title = "Determination of free thyroid hormones",
abstract = "Timely diagnosis and treatment of thyroid dysfunction is compelling given the prevalence and severity of the disease. It requires reliance on adequate laboratory testing of serum TSH as a hallmark in combination with free thyroxine/triiodothyronine. Free hormone methods have to accommodate variations in the concentration and binding capacity of binding proteins. This is a challenge because none of the methodologies developed so far measures the actual unbound hormone in serum. The indirect methods provide an approximation while the direct ones estimate the free hormone concentration either in the presence of the protein-bound counterpart, or after physical separation of the free from bound fraction. The ongoing controversy on the validity and lack of comparability of methodologies points to their imperfectness to reflect real in-vivo free hormone concentrations. Therefore, laboratories and clinicians should know the window of validity and limitations of their methods. The recently developed reference measurement system is a key advance towards improved standardization and clinical validity of free thyroid hormone measurements.",
author = "Lm Thienpont and {Van Uytfanghe}, K. and Kris Poppe and Brigitte Velkeniers-Hoebanckx",
year = "2013",
language = "English",
volume = "27",
pages = "689--700",
journal = "Best Practice & Research Clinical Endocrinology & Metabolism",
issn = "1521-690X",
publisher = "Bailliere Tindall Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Determination of free thyroid hormones

AU - Thienpont, Lm

AU - Van Uytfanghe, K.

AU - Poppe, Kris

AU - Velkeniers-Hoebanckx, Brigitte

PY - 2013

Y1 - 2013

N2 - Timely diagnosis and treatment of thyroid dysfunction is compelling given the prevalence and severity of the disease. It requires reliance on adequate laboratory testing of serum TSH as a hallmark in combination with free thyroxine/triiodothyronine. Free hormone methods have to accommodate variations in the concentration and binding capacity of binding proteins. This is a challenge because none of the methodologies developed so far measures the actual unbound hormone in serum. The indirect methods provide an approximation while the direct ones estimate the free hormone concentration either in the presence of the protein-bound counterpart, or after physical separation of the free from bound fraction. The ongoing controversy on the validity and lack of comparability of methodologies points to their imperfectness to reflect real in-vivo free hormone concentrations. Therefore, laboratories and clinicians should know the window of validity and limitations of their methods. The recently developed reference measurement system is a key advance towards improved standardization and clinical validity of free thyroid hormone measurements.

AB - Timely diagnosis and treatment of thyroid dysfunction is compelling given the prevalence and severity of the disease. It requires reliance on adequate laboratory testing of serum TSH as a hallmark in combination with free thyroxine/triiodothyronine. Free hormone methods have to accommodate variations in the concentration and binding capacity of binding proteins. This is a challenge because none of the methodologies developed so far measures the actual unbound hormone in serum. The indirect methods provide an approximation while the direct ones estimate the free hormone concentration either in the presence of the protein-bound counterpart, or after physical separation of the free from bound fraction. The ongoing controversy on the validity and lack of comparability of methodologies points to their imperfectness to reflect real in-vivo free hormone concentrations. Therefore, laboratories and clinicians should know the window of validity and limitations of their methods. The recently developed reference measurement system is a key advance towards improved standardization and clinical validity of free thyroid hormone measurements.

M3 - Article

VL - 27

SP - 689

EP - 700

JO - Best Practice & Research Clinical Endocrinology & Metabolism

JF - Best Practice & Research Clinical Endocrinology & Metabolism

SN - 1521-690X

IS - 5

ER -

ID: 2417246