BACKGROUND: Patients with Chronic Fatigue Syndrome (CFS) present a disordered sleep pattern and frequently undergo polysomnography to exclude a primary sleep disorder. Such studies have shown reduced sleep efficiency, a reduction of deep sleep, prolonged sleep initiation, and alpha wave intrusion during deep sleep. Deregulation of the 2-5A synthetase/RNase L antiviral pathway and a potential acquired channelopathy are also found in a subset of CFS patients and could lead to sleep disturbances. This manuscript compiles a large sleep study database on CFS patients and correlates these data with a limited number of immune parameters as it has been thought that RNase L could be associated with these sleep disturbances.
METHODS: Forty-eight patients who fulfilled 1994 CDC criteria for CFS underwent extensive medical evaluation, routine laboratory testing, and a structured psychiatric interview. Subjects then completed a complaint checklist and a two-night polysomnographic investigation. RNaseL analysis was performed by gel electrophoresis using a radiolabeled 2',5'-oligoadenylate trimer. Basic descriptive statistical parameters were calculated. RESULTS: Patients experienced a prolonged sleep latency, showed a low sleep efficiency index, and had a low percentage of slow wave sleep. The present alpha-delta intrusion correlated with anxiety; no correlations appeared however between alpha-delta sleep and immunological parameters including RNaseL.
CONCLUSIONS: The main findings are: (1) validation of sleep latency problems and other sleep disturbances as already suggested by several authors; (2) alpha delta intrusion seems associated with anxiety; and (3) elevated RNase L did not correlate with alpha-delta sleep.
Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalThe American Journal of Medical Sciences
Volume333
Issue number2
Publication statusPublished - 1 Mar 2007

    Research areas

  • alpha-delta sleep, chronic fatigue syndrome

ID: 1767758