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@article{666281621d0a4c79b2f273e7ee65c438,
title = "Cumulative live birth rates after IVF in patients with polycystic ovaries: phenotype matters",
abstract = "RESEARCH QUESTION: Do cumulative live birth rates (CLBR) vary among women with different polycystic ovary syndrome (PCOS) phenotypes who undergo IVF/intracytoplasmic sperm injection (ICSI) treatment?DESIGN: In this retrospective cohort study, data from 567 patients undergoing an assisted reproductive technology (ART) cycle between January 2010 and December 2015 were collected. Demographical traits, cycle characteristics and clinical and laboratory data were analysed.RESULTS: After conventional ovarian stimulation using a gonadotrophin-releasing hormone antagonist protocol, the median number of oocytes retrieved ranged between 11 and 13.5 and did not differ significantly among the studied groups. Live birth rate (LBR) after fresh embryo transfer and CLBR after transfer of all fresh and vitrified embryos were significantly lower in women with hyperandrogenic PCOS phenotypes A (LBR 16.7{\%}, CLBR 25.8{\%}) and C (LBR 18.5{\%}, CLBR 27.8{\%}) compared with women with normoandrogenic PCOS phenotype D (LBR 33.7{\%}, CLBR 48{\%}) (P-value for LBR 0.01 and 0.03, respectively; P-value for CLBR 0.002 and 0.01, respectively) and controls with a polycystic ovarian morphology (LBR 37.1{\%}, CLBR 53.3{\%}) (P-value for LBR 0.002 and 0.01, respectively; P-value for CLBR <0.001 and 0.001, respectively). Multivariate regression analysis indicated that after adjustment for relevant confounders, PCOS phenotype was an independent predictor for CLBR.CONCLUSIONS: Hyperandrogenic PCOS phenotypes confer significantly lower CLBR compared with their normoandrogenic counterparts. These findings may imply the need for adapted counselling and tailored approaches when treating PCOS patients with hyperandrogenism who require ART.",
keywords = "Assisted reproductive technology, Cumulative live birth rate, Hyperandrogenism, PCOM, PCOS",
author = "{De Vos}, Michel and St{\'e}phanie Pareyn and Panagiotis Drakopoulos and Raimundo, {Jos{\'e} M} and Ellen Anckaert and Samuel Santos-Ribeiro and Polyzos, {Nikolaos P} and Herman Tournaye and Christophe Blockeel",
note = "Copyright {\circledC} 2018 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.",
year = "2018",
month = "8",
doi = "10.1016/j.rbmo.2018.05.003",
language = "English",
volume = "37",
pages = "163--171",
journal = "Reproductive BioMedicine Online",
issn = "1472-6483",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Cumulative live birth rates after IVF in patients with polycystic ovaries

T2 - phenotype matters

AU - De Vos, Michel

AU - Pareyn, Stéphanie

AU - Drakopoulos, Panagiotis

AU - Raimundo, José M

AU - Anckaert, Ellen

AU - Santos-Ribeiro, Samuel

AU - Polyzos, Nikolaos P

AU - Tournaye, Herman

AU - Blockeel, Christophe

N1 - Copyright © 2018 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

PY - 2018/8

Y1 - 2018/8

N2 - RESEARCH QUESTION: Do cumulative live birth rates (CLBR) vary among women with different polycystic ovary syndrome (PCOS) phenotypes who undergo IVF/intracytoplasmic sperm injection (ICSI) treatment?DESIGN: In this retrospective cohort study, data from 567 patients undergoing an assisted reproductive technology (ART) cycle between January 2010 and December 2015 were collected. Demographical traits, cycle characteristics and clinical and laboratory data were analysed.RESULTS: After conventional ovarian stimulation using a gonadotrophin-releasing hormone antagonist protocol, the median number of oocytes retrieved ranged between 11 and 13.5 and did not differ significantly among the studied groups. Live birth rate (LBR) after fresh embryo transfer and CLBR after transfer of all fresh and vitrified embryos were significantly lower in women with hyperandrogenic PCOS phenotypes A (LBR 16.7%, CLBR 25.8%) and C (LBR 18.5%, CLBR 27.8%) compared with women with normoandrogenic PCOS phenotype D (LBR 33.7%, CLBR 48%) (P-value for LBR 0.01 and 0.03, respectively; P-value for CLBR 0.002 and 0.01, respectively) and controls with a polycystic ovarian morphology (LBR 37.1%, CLBR 53.3%) (P-value for LBR 0.002 and 0.01, respectively; P-value for CLBR <0.001 and 0.001, respectively). Multivariate regression analysis indicated that after adjustment for relevant confounders, PCOS phenotype was an independent predictor for CLBR.CONCLUSIONS: Hyperandrogenic PCOS phenotypes confer significantly lower CLBR compared with their normoandrogenic counterparts. These findings may imply the need for adapted counselling and tailored approaches when treating PCOS patients with hyperandrogenism who require ART.

AB - RESEARCH QUESTION: Do cumulative live birth rates (CLBR) vary among women with different polycystic ovary syndrome (PCOS) phenotypes who undergo IVF/intracytoplasmic sperm injection (ICSI) treatment?DESIGN: In this retrospective cohort study, data from 567 patients undergoing an assisted reproductive technology (ART) cycle between January 2010 and December 2015 were collected. Demographical traits, cycle characteristics and clinical and laboratory data were analysed.RESULTS: After conventional ovarian stimulation using a gonadotrophin-releasing hormone antagonist protocol, the median number of oocytes retrieved ranged between 11 and 13.5 and did not differ significantly among the studied groups. Live birth rate (LBR) after fresh embryo transfer and CLBR after transfer of all fresh and vitrified embryos were significantly lower in women with hyperandrogenic PCOS phenotypes A (LBR 16.7%, CLBR 25.8%) and C (LBR 18.5%, CLBR 27.8%) compared with women with normoandrogenic PCOS phenotype D (LBR 33.7%, CLBR 48%) (P-value for LBR 0.01 and 0.03, respectively; P-value for CLBR 0.002 and 0.01, respectively) and controls with a polycystic ovarian morphology (LBR 37.1%, CLBR 53.3%) (P-value for LBR 0.002 and 0.01, respectively; P-value for CLBR <0.001 and 0.001, respectively). Multivariate regression analysis indicated that after adjustment for relevant confounders, PCOS phenotype was an independent predictor for CLBR.CONCLUSIONS: Hyperandrogenic PCOS phenotypes confer significantly lower CLBR compared with their normoandrogenic counterparts. These findings may imply the need for adapted counselling and tailored approaches when treating PCOS patients with hyperandrogenism who require ART.

KW - Assisted reproductive technology

KW - Cumulative live birth rate

KW - Hyperandrogenism

KW - PCOM

KW - PCOS

UR - http://www.scopus.com/inward/record.url?scp=85046866790&partnerID=8YFLogxK

U2 - 10.1016/j.rbmo.2018.05.003

DO - 10.1016/j.rbmo.2018.05.003

M3 - Article

C2 - 29778554

VL - 37

SP - 163

EP - 171

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

SN - 1472-6483

IS - 2

ER -

ID: 39173968