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Coinfection With Trypanosoma brucei Confers Protection Against Cutaneous Leishmaniasis. / Pereira, Lais; Oliveira, Fabiano; Townsend, Shannon; Metangmo, Sonia; Meneses, Claudio; Moore, Ian N.; Brodskyn, Claudia I.; Valenzuela, Jesus G.; Magez, Stefan; Kamhawi, Shaden.

In: Frontiers in Immunology, Vol. 9, 2855, 11.12.2018, p. 2855.

Research output: Contribution to journalArticleResearchpeer-review

Harvard

Pereira, L, Oliveira, F, Townsend, S, Metangmo, S, Meneses, C, Moore, IN, Brodskyn, CI, Valenzuela, JG, Magez, S & Kamhawi, S 2018, 'Coinfection With Trypanosoma brucei Confers Protection Against Cutaneous Leishmaniasis' Frontiers in Immunology, vol. 9, 2855, pp. 2855. https://doi.org/10.3389/fimmu.2018.02855

APA

Pereira, L., Oliveira, F., Townsend, S., Metangmo, S., Meneses, C., Moore, I. N., ... Kamhawi, S. (2018). Coinfection With Trypanosoma brucei Confers Protection Against Cutaneous Leishmaniasis. Frontiers in Immunology, 9, 2855. [2855]. https://doi.org/10.3389/fimmu.2018.02855

Vancouver

Pereira L, Oliveira F, Townsend S, Metangmo S, Meneses C, Moore IN et al. Coinfection With Trypanosoma brucei Confers Protection Against Cutaneous Leishmaniasis. Frontiers in Immunology. 2018 Dec 11;9:2855. 2855. https://doi.org/10.3389/fimmu.2018.02855

Author

Pereira, Lais ; Oliveira, Fabiano ; Townsend, Shannon ; Metangmo, Sonia ; Meneses, Claudio ; Moore, Ian N. ; Brodskyn, Claudia I. ; Valenzuela, Jesus G. ; Magez, Stefan ; Kamhawi, Shaden. / Coinfection With Trypanosoma brucei Confers Protection Against Cutaneous Leishmaniasis. In: Frontiers in Immunology. 2018 ; Vol. 9. pp. 2855.

BibTeX

@article{848de8b0465c4b9ba79a2f7e8bce2324,
title = "Coinfection With Trypanosoma brucei Confers Protection Against Cutaneous Leishmaniasis",
abstract = "Infection with certain bacteria, parasites, and viruses alters the host immune system to Leishmania major influencing disease outcome. Here, we determined the outcome of a chronic infection with Trypanosoma brucei brucei on cutaneous leishmaniasis (CL) caused by L. major. C57BL/6 mice infected with T. b. brucei were given a sub-curative treatment with diminazene aceturate then coinfected with L. major by vector bites. Our results revealed that infection with T. b. brucei controls CL pathology. Compared to controls, coinfected mice showed a significant decrease in lesion size ( P < 0.05) up to 6 weeks post-infection and a significant decrease in parasite burden ( P < 0.0001) at 3 weeks post-infection. Protection against L. major resulted from a non-specific activation of T cells by trypanosomes. This induced a strong immune response characterized by IFN-γ production at the site of bites and systemically, creating a hostile inflammatory environment for L. major parasites and conferring protection from CL.",
keywords = "cellular immunity, coinfection, cutaneous leishmaniasis, humoral immunity, inflammation, Leishmania major, protection, Trypanosoma brucei",
author = "Lais Pereira and Fabiano Oliveira and Shannon Townsend and Sonia Metangmo and Claudio Meneses and Moore, {Ian N.} and Brodskyn, {Claudia I.} and Valenzuela, {Jesus G.} and Stefan Magez and Shaden Kamhawi",
year = "2018",
month = "12",
day = "11",
doi = "10.3389/fimmu.2018.02855",
language = "English",
volume = "9",
pages = "2855",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Coinfection With Trypanosoma brucei Confers Protection Against Cutaneous Leishmaniasis

AU - Pereira, Lais

AU - Oliveira, Fabiano

AU - Townsend, Shannon

AU - Metangmo, Sonia

AU - Meneses, Claudio

AU - Moore, Ian N.

AU - Brodskyn, Claudia I.

AU - Valenzuela, Jesus G.

AU - Magez, Stefan

AU - Kamhawi, Shaden

PY - 2018/12/11

Y1 - 2018/12/11

N2 - Infection with certain bacteria, parasites, and viruses alters the host immune system to Leishmania major influencing disease outcome. Here, we determined the outcome of a chronic infection with Trypanosoma brucei brucei on cutaneous leishmaniasis (CL) caused by L. major. C57BL/6 mice infected with T. b. brucei were given a sub-curative treatment with diminazene aceturate then coinfected with L. major by vector bites. Our results revealed that infection with T. b. brucei controls CL pathology. Compared to controls, coinfected mice showed a significant decrease in lesion size ( P < 0.05) up to 6 weeks post-infection and a significant decrease in parasite burden ( P < 0.0001) at 3 weeks post-infection. Protection against L. major resulted from a non-specific activation of T cells by trypanosomes. This induced a strong immune response characterized by IFN-γ production at the site of bites and systemically, creating a hostile inflammatory environment for L. major parasites and conferring protection from CL.

AB - Infection with certain bacteria, parasites, and viruses alters the host immune system to Leishmania major influencing disease outcome. Here, we determined the outcome of a chronic infection with Trypanosoma brucei brucei on cutaneous leishmaniasis (CL) caused by L. major. C57BL/6 mice infected with T. b. brucei were given a sub-curative treatment with diminazene aceturate then coinfected with L. major by vector bites. Our results revealed that infection with T. b. brucei controls CL pathology. Compared to controls, coinfected mice showed a significant decrease in lesion size ( P < 0.05) up to 6 weeks post-infection and a significant decrease in parasite burden ( P < 0.0001) at 3 weeks post-infection. Protection against L. major resulted from a non-specific activation of T cells by trypanosomes. This induced a strong immune response characterized by IFN-γ production at the site of bites and systemically, creating a hostile inflammatory environment for L. major parasites and conferring protection from CL.

KW - cellular immunity

KW - coinfection

KW - cutaneous leishmaniasis

KW - humoral immunity

KW - inflammation

KW - Leishmania major

KW - protection

KW - Trypanosoma brucei

UR - http://www.scopus.com/inward/record.url?scp=85059929982&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2018.02855

DO - 10.3389/fimmu.2018.02855

M3 - Article

VL - 9

SP - 2855

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 2855

ER -

ID: 44755552