Improved treatments have led to an increased survival rate in cancer patients. However, in pre-pubertal boys, these gonadotoxic
treatments can result in the depletion of the spermatogonial stem cell (SSC) pool causing lifelong infertility. SSC transplantation has
been proposed as a promising technique to preserve the fertility of these patients. In mice, this technique has resulted in live-born
offspring, but the efficiency of colonization remained low. This could be because of a deficient microenvironment, leading to apoptosis
of the transplanted SSCs. Interestingly, mesenchymal stem cells (MSCs), being multipotent and easy to isolate and multiply
in vitro, are nowadays successfully and widely used in regenerative medicine. Here, we shortly review the current understanding of
MSC and SSC biology, and we hypothesize that a combined MSC-SSC transplantation might improve the efficiency of SSC colonization
and differentiation as paracrine factors from MSCs may contribute to the SSC niche.
Original languageEnglish
Pages (from-to)2-9
Number of pages8
Issue number1
StatePublished - Jan 2017

ID: 28546027