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@article{a61db59f4abb41a1b8d5de57d5ef0d67,
title = "Antibody-mediated control of Trypanosoma vivax infection fails in the absence of tumour necrosis factor",
abstract = "Trypanosoma vivax causes a wasting disease affecting livestock breeding and agriculture in developing countries of sub-Sahara Africa and South America. Being an extracellular parasite, control of T. vivax has been proposed to be mediated by host antibodies. However, the use of a comparative infection model of wild-type (WT) and tumour necrosis factor (TNF) knockout (TNF(-/-) ) mice shows that the latter is unable to control first-peak parasitaemia, despite the presence of specific antitrypanosome antibodies. In contrast, WT mice parasitaemia peak control coincides with a combined early onset of TNF production and induction of specific antibodies. TNF is mainly produced by liver-associated monocytes and neutrophils. In this study, no other correlation between cellular immunomodulations and peak parasitaemia control was observed, underscoring the importance of the role of TNF in the control of T. vivax infections.",
keywords = "Antibody, Innate immunity, Parasitaemia, Trypanosomosis",
author = "{La Greca Saint Esteven}, Florencia and Carole Haynes and Benoit Stijlemans and {De Trez}, Carl and Stefan Magez",
year = "2014",
month = "6",
day = "1",
language = "English",
volume = "36",
pages = "271--276",
journal = "Parasite Immunology",
issn = "0141-9838",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Antibody-mediated control of Trypanosoma vivax infection fails in the absence of tumour necrosis factor

AU - La Greca Saint Esteven, Florencia

AU - Haynes, Carole

AU - Stijlemans, Benoit

AU - De Trez, Carl

AU - Magez, Stefan

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Trypanosoma vivax causes a wasting disease affecting livestock breeding and agriculture in developing countries of sub-Sahara Africa and South America. Being an extracellular parasite, control of T. vivax has been proposed to be mediated by host antibodies. However, the use of a comparative infection model of wild-type (WT) and tumour necrosis factor (TNF) knockout (TNF(-/-) ) mice shows that the latter is unable to control first-peak parasitaemia, despite the presence of specific antitrypanosome antibodies. In contrast, WT mice parasitaemia peak control coincides with a combined early onset of TNF production and induction of specific antibodies. TNF is mainly produced by liver-associated monocytes and neutrophils. In this study, no other correlation between cellular immunomodulations and peak parasitaemia control was observed, underscoring the importance of the role of TNF in the control of T. vivax infections.

AB - Trypanosoma vivax causes a wasting disease affecting livestock breeding and agriculture in developing countries of sub-Sahara Africa and South America. Being an extracellular parasite, control of T. vivax has been proposed to be mediated by host antibodies. However, the use of a comparative infection model of wild-type (WT) and tumour necrosis factor (TNF) knockout (TNF(-/-) ) mice shows that the latter is unable to control first-peak parasitaemia, despite the presence of specific antitrypanosome antibodies. In contrast, WT mice parasitaemia peak control coincides with a combined early onset of TNF production and induction of specific antibodies. TNF is mainly produced by liver-associated monocytes and neutrophils. In this study, no other correlation between cellular immunomodulations and peak parasitaemia control was observed, underscoring the importance of the role of TNF in the control of T. vivax infections.

KW - Antibody

KW - Innate immunity

KW - Parasitaemia

KW - Trypanosomosis

M3 - Article

VL - 36

SP - 271

EP - 276

JO - Parasite Immunology

JF - Parasite Immunology

SN - 0141-9838

IS - 6

ER -

ID: 2511644