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Analytical techniques for metabolomic studies : a review. / Segers, Karen; Declerck, Sven; Mangelings, Debby; Heyden, Yvan Vander; Eeckhaut, Ann Van.

In: Bioanalysis, Vol. 11, No. 24, 17.12.2019, p. 2297-2318.

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@article{1acdb2626e5a48ff9b802a02b97af133,
title = "Analytical techniques for metabolomic studies: a review",
abstract = "Metabolomics is the comprehensive study of small-molecule metabolites. Obtaining a wide coverage of the metabolome is challenging because of the broad range of physicochemical properties of the small molecules. To study the compounds of interest spectroscopic (NMR), spectrometric (MS) and separation techniques (LC, GC, supercritical fluid chromatography, CE) are used. The choice for a given technique is influenced by the sample matrix, the concentration and properties of the metabolites, and the amount of sample. This review discusses the most commonly used analytical techniques for metabolomic studies, including their advantages, drawbacks and some applications.",
keywords = "multiplatform approaches, separation techniques, spectrometric techniques, spectroscopic techniques, targeted metabolomics, untargeted metabolomics",
author = "Karen Segers and Sven Declerck and Debby Mangelings and Heyden, {Yvan Vander} and Eeckhaut, {Ann Van}",
year = "2019",
month = "12",
day = "17",
doi = "10.4155/bio-2019-0014",
language = "English",
volume = "11",
pages = "2297--2318",
journal = "Bioanalysis",
issn = "1757-6180",
publisher = "Future Science",
number = "24",

}

RIS

TY - JOUR

T1 - Analytical techniques for metabolomic studies

T2 - a review

AU - Segers, Karen

AU - Declerck, Sven

AU - Mangelings, Debby

AU - Heyden, Yvan Vander

AU - Eeckhaut, Ann Van

PY - 2019/12/17

Y1 - 2019/12/17

N2 - Metabolomics is the comprehensive study of small-molecule metabolites. Obtaining a wide coverage of the metabolome is challenging because of the broad range of physicochemical properties of the small molecules. To study the compounds of interest spectroscopic (NMR), spectrometric (MS) and separation techniques (LC, GC, supercritical fluid chromatography, CE) are used. The choice for a given technique is influenced by the sample matrix, the concentration and properties of the metabolites, and the amount of sample. This review discusses the most commonly used analytical techniques for metabolomic studies, including their advantages, drawbacks and some applications.

AB - Metabolomics is the comprehensive study of small-molecule metabolites. Obtaining a wide coverage of the metabolome is challenging because of the broad range of physicochemical properties of the small molecules. To study the compounds of interest spectroscopic (NMR), spectrometric (MS) and separation techniques (LC, GC, supercritical fluid chromatography, CE) are used. The choice for a given technique is influenced by the sample matrix, the concentration and properties of the metabolites, and the amount of sample. This review discusses the most commonly used analytical techniques for metabolomic studies, including their advantages, drawbacks and some applications.

KW - multiplatform approaches, separation techniques, spectrometric techniques, spectroscopic techniques, targeted metabolomics, untargeted metabolomics

UR - http://www.scopus.com/inward/record.url?scp=85076690717&partnerID=8YFLogxK

U2 - 10.4155/bio-2019-0014

DO - 10.4155/bio-2019-0014

M3 - Article

C2 - 31845604

VL - 11

SP - 2297

EP - 2318

JO - Bioanalysis

JF - Bioanalysis

SN - 1757-6180

IS - 24

ER -

ID: 48826680