Tricyclic compounds call the attention because of their pharmacological properties, and are considered a preferred platform for the development of drugs. Especially, in cancer treatment, these planar compounds are known for their ability to stack with DNA base pairs, acting as intercalators. In this sense,
natural products (NPs) are a prodigal source of polycyclic compounds, comprising classes, such as carbolines, anthraquinones and xanthones. However, most of these compounds lack suitable physicochemical
properties, compatible to oral bioaviability. In this perspective, this paper aims to overview the role of tricyclic cores in the development of cytotoxic compounds, focusing on the leadlikeness estimation of the most prominent NP classes and their synthetic derivatives.
Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalEuropean Journal of Medicinal Chemistry
Volume166
DOIs
Publication statusPublished - 15 Mar 2019

    Research areas

  • Cancer, Cytotoxic, Hit-to-lead, Leadlikeness, Xanthone

ID: 43910448