The present study speculates on the potential gain we can expect of a further leap in pressure by moving from the current 1500 bar to a futuristic 3000 bar as well as reviews the main impediments to be expected when trying to realize such systems. The study focuses on so-called "analytical scale" separations, i.e., separations that are currently carried out in 2.1 mm columns, as this is the current state-of-the-art in ultrahigh-pressure liquid chromatography (UHPLC) instrumentation.
Original languageEnglish
Pages (from-to)554-560
Number of pages6
JournalAnalytical Chemistry
Issue number1
Publication statusPublished - 7 Jan 2020

    Research areas

  • Band Broadening Contributions, Kinetic Performance, Core-Shell, MU-M, Representation Methods, Temperature-Gradients, Operating Pressure, Heat Dissipation, Practical Method, Efficiency

ID: 49202630