Standard

Absence of glutamate release via system xc- decreases anxiety and depressive-like behaviour in mice. / Bentea, Eduard-Mihai; Demuyser, Thomas; Albertini, Giulia; Van Liefferinge, Joeri; Merckx, Ellen; Sato, Hideyo; Michotte, Yvette; Smolders, Ilse Julia; Massie, Ann.

Research in Psychiatry Day organized by the Belgian College for Neuropsychopharmacology and Biological Psychiatry, 27 September 2013, Leuven. 2013.

Research output: Chapter in Book/Report/Conference proceedingMeeting abstract (Book)

Harvard

Bentea, E-M, Demuyser, T, Albertini, G, Van Liefferinge, J, Merckx, E, Sato, H, Michotte, Y, Smolders, IJ & Massie, A 2013, Absence of glutamate release via system xc- decreases anxiety and depressive-like behaviour in mice. in Research in Psychiatry Day organized by the Belgian College for Neuropsychopharmacology and Biological Psychiatry, 27 September 2013, Leuven.

APA

Bentea, E-M., Demuyser, T., Albertini, G., Van Liefferinge, J., Merckx, E., Sato, H., ... Massie, A. (2013). Absence of glutamate release via system xc- decreases anxiety and depressive-like behaviour in mice. In Research in Psychiatry Day organized by the Belgian College for Neuropsychopharmacology and Biological Psychiatry, 27 September 2013, Leuven

Vancouver

Bentea E-M, Demuyser T, Albertini G, Van Liefferinge J, Merckx E, Sato H et al. Absence of glutamate release via system xc- decreases anxiety and depressive-like behaviour in mice. In Research in Psychiatry Day organized by the Belgian College for Neuropsychopharmacology and Biological Psychiatry, 27 September 2013, Leuven. 2013

Author

BibTeX

@inbook{deded595d55f4aeda377cc129254a1f9,
title = "Absence of glutamate release via system xc- decreases anxiety and depressive-like behaviour in mice",
abstract = "Depression and anxiety disorders are some of the most common and important health problems worldwide. The current therapeutic approaches for these psychiatric conditions are often limited in efficacy, and may be associated with serious side effects, such as sedation, memory impairment, or physical dependence. Therefore, novel pharmacological targets with an improved therapeutic profile are currently of urgent need. System xc- is a plasma membrane transporter that imports cystine and exports glutamate in the extracellular space. Although system xc- can act as a source of extrasynaptic glutamate release, the physiologic role played by this transporter in neurotransmission and behavior has been difficult to unravel due to the lack of selective inhibitors. In order to elucidate the role played by system xc- in vivo, we have recently characterized the behavioral changes observed after transgenic loss of xCT (the specific subunit of system xc-) in mice. Interestingly, preliminary data indicate that xCT knock-out mice show an anxiolytic and antidepressant-like phenotype, as evidenced by significant changes in parameters obtained from anxiety-based tests (open-field and light/dark tests), and depression-based test (forced swim test). This shift in behavior occurred in the absence of significant changes in motor behavior, as evidenced by a battery of motor tests, such as the open-field, rotarod, nest building, and adhesive removal tests, and was stable across ageing, indicating the presence of an endophenotype in the xCT knock-out mice. These novel findings extend the previous observations that targeting the glutamatergic system might form the basis of novel therapeutic interventions for mood disorders. Furthermore, they confirm an active participation of nonsynaptic glutamate release, to behavioral traits in physiological conditions. In conclusion, our data strongly suggest that targeting system xc- might represent a novel therapeutic intervention for mood disorders.",
keywords = "system xc-, depression, anxiety, glutamate",
author = "Eduard-Mihai Bentea and Thomas Demuyser and Giulia Albertini and {Van Liefferinge}, Joeri and Ellen Merckx and Hideyo Sato and Yvette Michotte and Smolders, {Ilse Julia} and Ann Massie",
year = "2013",
month = "9",
day = "27",
language = "English",
booktitle = "Research in Psychiatry Day organized by the Belgian College for Neuropsychopharmacology and Biological Psychiatry, 27 September 2013, Leuven",

}

RIS

TY - CHAP

T1 - Absence of glutamate release via system xc- decreases anxiety and depressive-like behaviour in mice

AU - Bentea, Eduard-Mihai

AU - Demuyser, Thomas

AU - Albertini, Giulia

AU - Van Liefferinge, Joeri

AU - Merckx, Ellen

AU - Sato, Hideyo

AU - Michotte, Yvette

AU - Smolders, Ilse Julia

AU - Massie, Ann

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Depression and anxiety disorders are some of the most common and important health problems worldwide. The current therapeutic approaches for these psychiatric conditions are often limited in efficacy, and may be associated with serious side effects, such as sedation, memory impairment, or physical dependence. Therefore, novel pharmacological targets with an improved therapeutic profile are currently of urgent need. System xc- is a plasma membrane transporter that imports cystine and exports glutamate in the extracellular space. Although system xc- can act as a source of extrasynaptic glutamate release, the physiologic role played by this transporter in neurotransmission and behavior has been difficult to unravel due to the lack of selective inhibitors. In order to elucidate the role played by system xc- in vivo, we have recently characterized the behavioral changes observed after transgenic loss of xCT (the specific subunit of system xc-) in mice. Interestingly, preliminary data indicate that xCT knock-out mice show an anxiolytic and antidepressant-like phenotype, as evidenced by significant changes in parameters obtained from anxiety-based tests (open-field and light/dark tests), and depression-based test (forced swim test). This shift in behavior occurred in the absence of significant changes in motor behavior, as evidenced by a battery of motor tests, such as the open-field, rotarod, nest building, and adhesive removal tests, and was stable across ageing, indicating the presence of an endophenotype in the xCT knock-out mice. These novel findings extend the previous observations that targeting the glutamatergic system might form the basis of novel therapeutic interventions for mood disorders. Furthermore, they confirm an active participation of nonsynaptic glutamate release, to behavioral traits in physiological conditions. In conclusion, our data strongly suggest that targeting system xc- might represent a novel therapeutic intervention for mood disorders.

AB - Depression and anxiety disorders are some of the most common and important health problems worldwide. The current therapeutic approaches for these psychiatric conditions are often limited in efficacy, and may be associated with serious side effects, such as sedation, memory impairment, or physical dependence. Therefore, novel pharmacological targets with an improved therapeutic profile are currently of urgent need. System xc- is a plasma membrane transporter that imports cystine and exports glutamate in the extracellular space. Although system xc- can act as a source of extrasynaptic glutamate release, the physiologic role played by this transporter in neurotransmission and behavior has been difficult to unravel due to the lack of selective inhibitors. In order to elucidate the role played by system xc- in vivo, we have recently characterized the behavioral changes observed after transgenic loss of xCT (the specific subunit of system xc-) in mice. Interestingly, preliminary data indicate that xCT knock-out mice show an anxiolytic and antidepressant-like phenotype, as evidenced by significant changes in parameters obtained from anxiety-based tests (open-field and light/dark tests), and depression-based test (forced swim test). This shift in behavior occurred in the absence of significant changes in motor behavior, as evidenced by a battery of motor tests, such as the open-field, rotarod, nest building, and adhesive removal tests, and was stable across ageing, indicating the presence of an endophenotype in the xCT knock-out mice. These novel findings extend the previous observations that targeting the glutamatergic system might form the basis of novel therapeutic interventions for mood disorders. Furthermore, they confirm an active participation of nonsynaptic glutamate release, to behavioral traits in physiological conditions. In conclusion, our data strongly suggest that targeting system xc- might represent a novel therapeutic intervention for mood disorders.

KW - system xc-

KW - depression

KW - anxiety

KW - glutamate

M3 - Meeting abstract (Book)

BT - Research in Psychiatry Day organized by the Belgian College for Neuropsychopharmacology and Biological Psychiatry, 27 September 2013, Leuven

ER -

ID: 2357088