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A Tunable Freeform-Segmented Reflector in a Microfluidic System for Conventional and Surface-Enhanced Raman Spectroscopy. / Liu, Qing; Stenbæk Schmidt, Michael; Thienpont, Hugo; Ottevaere, Prof. Dr. Ir. Heidi.

In: Sensors, Vol. 20, No. 5, 25.02.2020, p. 1-15.

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@misc{974da8ba1dac417fb8ef71c38f09ef15,
title = "A Tunable Freeform-Segmented Reflector in a Microfluidic System for Conventional and Surface-Enhanced Raman Spectroscopy",
abstract = "We present a freeform-segmented reflector-based microfluidic system for conventional Raman and Surface-Enhanced Raman Scattering (SERS) analysis. The segmented reflector is directly designed by a numerical approach. The polymer-based Raman system strongly suppresses the undesirable background because it enables confocal detection of Raman scattering through the combination of a freeform reflector and a microfluidic chip. We perform systematic simulations using non-sequential ray tracing with the Henyey-Greenstein model to assess the Raman scattering behavior of the substance under test. We fabricate the freeform reflector and the microfluidic chip by means of ultra-precision diamond turning and laser cutting respectively. We demonstrate the confocal behavior by measuring the Raman spectrum of ethanol. Besides, we calibrate the setup by performing Raman measurements on urea and potassium nitrate solutions with different concentrations. The detection limit of our microfluidic system is approximately 20 mM according to the experiment. Finally, we implement a SERS microfluidic chip and discriminate 100 mu M urea and potassium nitrate solutions.",
keywords = "microfluidics, freeform surface, Raman spectroscopy, Photonics, optical detection, DEVICE; IDENTIFICATION; SENSOR; CELLS",
author = "Qing Liu and {Stenb{\ae}k Schmidt}, Michael and Hugo Thienpont and Ottevaere, {Prof. Dr. Ir. Heidi}",
year = "2020",
month = "2",
day = "25",
doi = "https://doi.org/10.3390/s20051250",
language = "English",
volume = "20",
pages = "1--15",
journal = "Sensors",
issn = "1424-8220",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

}

RIS

TY - GEN

T1 - A Tunable Freeform-Segmented Reflector in a Microfluidic System for Conventional and Surface-Enhanced Raman Spectroscopy

AU - Liu, Qing

AU - Stenbæk Schmidt, Michael

AU - Thienpont, Hugo

AU - Ottevaere, Prof. Dr. Ir. Heidi

PY - 2020/2/25

Y1 - 2020/2/25

N2 - We present a freeform-segmented reflector-based microfluidic system for conventional Raman and Surface-Enhanced Raman Scattering (SERS) analysis. The segmented reflector is directly designed by a numerical approach. The polymer-based Raman system strongly suppresses the undesirable background because it enables confocal detection of Raman scattering through the combination of a freeform reflector and a microfluidic chip. We perform systematic simulations using non-sequential ray tracing with the Henyey-Greenstein model to assess the Raman scattering behavior of the substance under test. We fabricate the freeform reflector and the microfluidic chip by means of ultra-precision diamond turning and laser cutting respectively. We demonstrate the confocal behavior by measuring the Raman spectrum of ethanol. Besides, we calibrate the setup by performing Raman measurements on urea and potassium nitrate solutions with different concentrations. The detection limit of our microfluidic system is approximately 20 mM according to the experiment. Finally, we implement a SERS microfluidic chip and discriminate 100 mu M urea and potassium nitrate solutions.

AB - We present a freeform-segmented reflector-based microfluidic system for conventional Raman and Surface-Enhanced Raman Scattering (SERS) analysis. The segmented reflector is directly designed by a numerical approach. The polymer-based Raman system strongly suppresses the undesirable background because it enables confocal detection of Raman scattering through the combination of a freeform reflector and a microfluidic chip. We perform systematic simulations using non-sequential ray tracing with the Henyey-Greenstein model to assess the Raman scattering behavior of the substance under test. We fabricate the freeform reflector and the microfluidic chip by means of ultra-precision diamond turning and laser cutting respectively. We demonstrate the confocal behavior by measuring the Raman spectrum of ethanol. Besides, we calibrate the setup by performing Raman measurements on urea and potassium nitrate solutions with different concentrations. The detection limit of our microfluidic system is approximately 20 mM according to the experiment. Finally, we implement a SERS microfluidic chip and discriminate 100 mu M urea and potassium nitrate solutions.

KW - microfluidics

KW - freeform surface

KW - Raman spectroscopy

KW - Photonics

KW - optical detection

KW - DEVICE; IDENTIFICATION; SENSOR; CELLS

U2 - https://doi.org/10.3390/s20051250

DO - https://doi.org/10.3390/s20051250

M3 - Article

VL - 20

SP - 1

EP - 15

JO - Sensors

JF - Sensors

SN - 1424-8220

ER -

ID: 49571350