5'-nor-anhydrovinblastine (Navelbine®) is a hemisynthetic Vinca alkaloid for which a selectivity for mitotic microtubules has been demonstrated. In previous studies, we have demonstrated an anti-invasive effect of other Vinca alkaloids. Here the results of in vitro and in vivo assays concerning the effect of 5'-nor-anhydrovinblastine on growth and invasion of MO4 cells are presented. It is demonstrated that at cytostatic concentrations, 5'-nor-anhydrovinblastine also has an anti-invasive effect.

Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalAnticancer Research
Volume13
Issue number1
Publication statusPublished - 1 Jan 1993

    Research areas

  • 5'-nor-anhydrovinblastine, Directional migration, Invasion, MO4 cells, Navelbine®, Vinca alkaloids

ID: 51691324