Fatigue is an important characteristic in a number of central nervous system disorders (Multiple Sclerosis, Parkinson's disease), but is also an important limiting factor in the practice of daily live routine in the elderly. Fatigue during exercise can originate peripherally (muscular level), but recently it became clear that there is also a central (supraspinal) aspect of fatigue. The goal of the present research is to obtain better knowledge on neural adaptations and limiting mechanisms of fatigue during prolonged exercise. In. order to achieve this we apply a combination of the determination of muscle and central fatigue and manipulation of brain neurotransmission. In a first phase the effects of a fatiguing exercise protocol on supraspinal fatigue will be researched; then brain neurotransmission will be manipulated during an identical exercise protocol; after that the role environmental temperature plays in central fatigue is determined. Finally, the project will focus on patient populations with different degrees of afferent feedback (information send from body to brain), such as sedentary, elderly and patients with central nervous system diseases. This final phase can help us improve rehabilitation programs in specific target groups, and even stimulate the development of pharmacological treatments to diminish the effect of fatigue.
Effective start/end date1/10/1030/09/16

    Research areas

  • Sportinjuries, Training, Muscular Strength, Hypoxia, Physiology, Revalidation, Exercise

    Flemish discipline codes

  • Physiology
  • Cardiac and vascular medicine
  • Biophysics

ID: 3386772