At the most fundamental level, life and death correspond to order and disorder. Within a cell, all processes need to be orchestrated in a timely manner. Among all processes that need to be regulated, the cell cycle is among the most important and most fundamental. The cell cycle controls when a cell needs to divide. This needs to happen at exactly the right moment and in the right circumstances in order to avoid either death or cancerous growth. An important factor in cell cycle regulation are the so-called cyclin-dependent kinases (CDKs) who's action is blocked by specific inhibitors that react upon completion of an earlier phase in the cycle and on DNA damage.
Recently, a novel stress-induced family of CDK inhibitors has been discovered in plants called SIAMESE (SIM) and SIAMESE-related (SMR) proteins. Being unrelated in terms of amino acid sequence to other well-characterized CDK inhibitors, their mechanism of action remains unknown. In this project, I intend a first structural characterization of the SIM/SMR type of proteins using a combination of NMR spectroscopy, solution small angle X-ray scatter and molecular modeling.
Effective start/end date1/10/1230/09/13

    Research areas

  • Applied Biology

    Flemish discipline codes

  • Biological sciences

ID: 3493472