Macrophages are cells of the immune system that are often abundantly found within tumors. Depending on the type of macrophage prevalent, they can either support or suppress tumor growth. The macrophage type is not fixed, and so the same macrophage can change from one type to another by a mechanism that is currently not fully known. We can imagine macrophage typeswitching as a train approaching a railroad switch, and we need to direct the macrophages to the anti-tumoral track. There has been some evidence to suggest that the protein ASK1 could be playing the role of the lever that switches the tracks. The motor that controls the position of the lever, however, and thereby the track that the macrophage will take, is still unknown. In other cell types it has been shown that ASK1 interacts with a protein called peroxiredoxin-1 (Prdx1), which also regulates its activity. Here we hypothesize that Prdx1 regulation of ASK1 controls macrophage type switching. This work will focus on the biophysical and biochemical characterization of Prdx1 and ASK1 in order to understand how exactly this interaction occurs and is regulated. In the long run, our results could be used for the design of drugs to manipulate this interaction and force the macrophage onto the anti-tumoral track.
Short titleBackup mandate
Effective start/end date1/11/1931/10/20

    Flemish discipline codes

  • Molecular and cell biology not elsewhere classified

    Research areas

  • biology

ID: 47824930