The cancer stem cell model hypothesis is that only one small subpopulation of tumor cells, the cancer stem cell, is able to form new tumors. Important properties of these tumor-initiating cell that can renew itself and can form all the diverse cell types of the tumor. It has been suggested that this population is resistant to current therapies resulted in the relapse rate of patients. Several researchers have investigated the cancer stem cell hypothesis in haematological cancer, multiple myeloma. Cancer, characterized by the growth of malignant cells in the bone marrow is composed of a mixture of cells ranging from B-cells (CD138neg) into plasma blast / plasma cells (CD138pos). The project consists of the identification and characterization of MM stem cells in the immune competent 5TMM and syngeneic mouse model. For the identification of tumorigenic cell, clonogene and tumor-initiating capacity CD138neg CD138pos and populations are examined, but we will also look at the remaining tumor cells after treatment of the diseased mice. Next, the characteristics of the MM stem cell homing capabilities ranging from analysis, localization in the bone marrow, proliferation, cell cycle, self-renewal and resitence to more extensive examination of gene expression microarrays and kinome analysis.
Effective start/end date1/01/1031/12/11

    Flemish discipline codes

  • Basic sciences
  • Biological sciences

    Research areas

  • Stem Cell, Blood, Coagulation, Myeloma, Immunology, Microbiology, HLA, Hematology, Lymphoma, cancer, Bone Marrow Transplantation

ID: 3323669