Portal hypertension is a severe complication of cirrhosis and is characterized by ahigh pressure in the portal vein. It is generally accepted now that hepatic stellate cells play a central role in the pathogenesis of portal hypertension: contraction of HSC aroun sinuoids leads to increased vascular resistance.
To transfer contractile forces of a cell to the ECM, the cell needs contractile properties, a solid cytoskeleton and anchering in the ECM.
In this project we investigate the presence of functional contractile elements in HSC, more specifically myosin.
Effective start/end date1/10/0931/03/10

    Flemish discipline codes

  • Basic sciences
  • Biological sciences
  • Materials engineering

    Research areas

  • Tonic Pain, Dendritic Cells, Evoked Potentials, Bispecific Antibodies, Immunotherapy, Immunology, Oncology

ID: 3338835