Description

The highly virulent avian influenza strain H5N1 has now spread through over 40 countries in Asia, Middle East, Europe and Africa, and has already caused several billion euro in losses to poultry farmers. Bird-to-human transmission occurs with low frequency, however the mortality rate in infected humans is over 50%. Vaccination is considered as the most important measure to prevent pandemics. Although different types of influenza vaccines have been developed, scientists around the world are developing better vaccines, which are less expensive, easier to store and deliver, safer and more efficacious.
The aim of this project is to develop a plant-based veterinary oral vaccine to combat avian influenza in Vietnam. Hemagglutinin (HA) gene constructs, corresponding to H5N1 avian influenza strains isolated in Vietnam, will be expressed in plants under control of seed specific promoters and the immune responses induced by the seed expressed antigens and their value for oral vaccination against avian influenza will be evaluated.
AcronymDWTC199
StatusFinished
Effective start/end date1/11/0631/10/08

    Research areas

  • molecular farming, oral vaccine, soybean, Arabidopsis, H5N1, plant based vaccine, avian influenza

    Flemish discipline codes

  • Materials engineering

ID: 3178252