Clinical sciences

Postal address
Laarbeeklaan 101
1090
Brussels
Belgium

Supporting clinical sciences

Postal address
Laarbeeklaan 101
1090
Brussels
Belgium

Expertise

Sophie Hernot obtained her Master of Science in Bio-engineering from the Vrije Universiteit of Brussels. She completed her PhD thesis in Medical Sciences in 2011 on the use of microbubbles (ultrasound contrast agents) as well as Nanobodies for molecular imaging and drug delivery applications. As post-doctoral researcher, and since 2016 as assistant professor in the Laboratory of In vivo Cellular and Molecular Imaging (ICMI, VUB), her research interests are two-fold: 1) design and validation of nanobodies for optical imaging applications, and in particular towards a clinical translation for image-guided surgery, and 2) validation of nanobody-based molecular probes for identification and characterization of high-risk atherosclerotic lesions. In both cases, particular attention is given to the effects of the nanobody-structure and radioactive or fluorescence labeling of nanobodies on their pharmacokinetics. 

Expertise: 

- Nanobody labelling

- Non-invasive molecular imaging (optical and nuclear imaging)

- Intra-operative imaging

- Preclinical animal models

Research output

  1. Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis

    Research output: Contribution to journalArticleResearchpeer-review

  2. Size And Affinity Kinetics Of Nanobodies Influence Penetration And Targeting Of Solid Tumours

    Research output: Unpublished contribution to conferencePosterResearch

  3. Latest developments in molecular tracers for fluorescence image-guided cancer surgery

    Research output: Contribution to journalScientific reviewResearchpeer-review

View all (103) »

Activities

  1. Design And Preclinical Evaluation Of A Single-label Bimodal Nanobody Tracer For Image-guided Surgery

    Activity: Talk or presentationTalk or presentation at a conference

  2. Nanobody-Based Molecular Tracers in Nuclear Imaging and Image-Guided Surgery

    Activity: Talk or presentationTalk or presentation at a conference

  3. Fluorescence-guided surgery of brain tumors using Nanobodies

    Activity: Talk or presentationTalk or presentation at a conference

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Prizes

  1. Travel Grant WMIC 2015

    Prize: Prize (including medals and awards)

  2. Nomination Marie Curie Award

    Prize: Prize (including medals and awards)

  3. Nomination Marie Curie Award

    Prize: Prize (including medals and awards)

View all (9) »

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