Department of Bio-engineering Sciences

Postal address
Pleinlaan 2
1050
Brussels
Belgium
Contact
Phone: +32-2-3590248

Structural Biology Brussels

Postal address
Pleinlaan 2
1050
Brussels
Belgium

Expertise

Last years, the Steyaert lab pioneered the use of nanobodies for chaperone-assisted X-ray crystallography (www.steyaertlab.eu), aiming at the highest hanging fruits of structural biology including membrane proteins, amyloidogenic proteins, and now also (transient) multiprotein complexes. The elucidation of the first GPCR structures in the agonist-bound active state demonstrate the power of Nanobodies to stabilize G protein coupled receptor conformational states including transmembrane signalling complexes. Recent work focusses on exploiting the conformational complexity of therapeutic targets for Nanobody-enabled drug discovery.

Research output

  1. Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion

    Research output: Contribution to journalArticleResearchpeer-review

  2. Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex

    Research output: Contribution to journalArticleResearchpeer-review

  3. Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax

    Research output: Contribution to journalArticleResearchpeer-review

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Activities

  1. 42d FEBS Congress

    Activity: Talk or presentationTalk or presentation at a conference

  2. Lezing voor Internationalisation@Home

    Activity: Talk or presentationTalk at an external academic organisation

  3. EU project 731005 - INSTRUCT-ULTRA

    Activity: Participating in or organising an eventParticipation in workshop, seminar

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